Precision Medicine, AI and the Science of Personalized Healthcare

Foreword xvii
Preface xix
Introduction: The Dawn of a New Era xxi
Chapter 1 Michael and Jennifer: A Family's Fight Against Obesity 1
Michael: The Silent Fighter 3
Jennifer: The Hopeful Realist 6
The Wearable Catalyst 10
A Hopeful Future 19
Chapter 2 Wearable Devices 21
Chronic Conditions: A Growing Concern 22
Wearables and Precision Medicine: Tailoring Health Solutions 28
Costs and Outcomes of Wearable Devices: Traditional vs. Precision Medicine 42
Notes 53
Chapter 3 The Science of Hope 59
Simplifying Precision Medicine 60
How It Works: From Data to Decisions 60
The Patient Perspective: Benefits Made Simple 62
Understanding the Impact of Wearables, Pharmacogenomics, Big Data Analytics, and Artificial Intelligence 65
Macro-Level Cost and Outcomes 70
The Universal Benefits of Precision Medicine 75
Notes 80
Chapter 4 Emily's Unrest 85
A Life of Contrasts 85
Breaking Point 93
Pharmacogenomics: A Tailored Solution 100
A Renewed Emily 103
Chapter 5 Genetics and Medication Management 107
Medication Failure in Traditional Care 108
Precision Medicine's Approach: Eliminating Trial and Error 113 The Role of Pharmacogenomics in Precision Medicine 122 Comparison of Cost and Outcomes: Traditional vs. Precision Medicine 129
Notes 134
Chapter 6 Through the Lens Clearly 141
Assembling the Pieces: The History of Medical Innovation 142
Implementing the Insights: From Bloodletting to Precision Medicine 152
Integrating the Outcomes: The Rise of Individualized Care 158
Notes 164
Chapter 7 The Joy and Pain of Being Amy 167
The Value of Work 168
A Lifetime of Shrugged Shoulders 172
A Voice of Concern 175
Treating the Person, Not the Symptoms 176
The Power of Knowing Why 177
It Takes a Village 180
Chapter 8 Pain and Personalized Therapy 185
The Hidden Epidemic of Pain 186
Data as Cure 191
Precision Pain Management in Action 198
Cost and Outcomes of Precision Pain Management 200
Notes 205
Chapter 9 Barriers to Access 209
The Challenges of Precision Medicine 210
Social Determinants of Health and Access to Care 217
Notes 221
Chapter 10 Susan, Family, and Cancer 223
Peggy Sue Got Married 223
The Family Years 225
Tuesday Afternoon 226
A Different Kind of Doctor 228
The Machine That Thinks 229
Moving the Mountain 232
A Life Reclaimed 234
Chapter 11 Artificial Intelligence and the Human Genome 237
The Intersection of Information and Artificial Intelligence 238
Genetic and Genomic Medicine 242
Cost and Outcomes: Advanced Personalized Treatments 252
Companies Shaping the Future of AI-Enabled Medicine 259
Notes 263
Chapter 12 A Vision for the Future 271
What's Next for Precision Medicine 272
Implications for Traditional Medicine 277
How Precision Medicine Will Shape Personalized Healthcare 283
Notes 287
Conclusion: Making Medicine Personal 289
The Personal Healthcare Journey 291
Common Themes from our Guides: What We Can Learn 294
How You Can Explore Precision Medicine for Yourself 296
Call to Action: A Roadmap for Leaders, Investors, and Policymakers 299
Notes 302
Acknowledgments 303
About the Author 305
Index 307