Substance P: From Pain to Cancer, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, provides a complete discussion of substance P biology, its role in normal physiology and a variety of diseases.The volume provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including cardiovascular function, micturition, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including acute brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The book closes with a look towards future perspectives for substance P.Substance P: From Pain to Cancer is an ideal reference for researchers across the life sciences interested in understanding the role of this multi-functioning mediator and its biological significance.
- Provides a comprehensive overview of the role of substance P across different organ systems, including the nervous, cardiovascular and musculoskeletal systems and renal function
- Includes detailed coverage of the specific actions of substance P in various disease states and conditions, such as inflammation, cancer, acute brain injury, mood disorders, Parkinson's disease, Alzheimer's disease and viral infection including COVID-19
- Examines substance P as a modulator of the immune response and pain perception
- Includes expertise from a range of interdisciplinary areas including molecular biology, pharmacology, physiology, neuroscience, anatomy, and therapeutics
Sprache
Verlagsort
Dateigröße
ISBN-13
978-0-443-22195-8 (9780443221958)
Schweitzer Klassifikation
1. The synthesis, release, and binding of substance PBrendan A. Hilliard, Robert Vink, and Mary F. Barbe2. Distribution of substance P receptors in mammalsHonoo Satake, Akira Shiraishi, and Tsuyoshi Kawada3. Substance P in nonmammalian biology: Evolutionarily conserved tachykinin signalingDick R. Nassel4. Methodological foundations of substance P detectionNuray Erin5. Substance P receptor antagonistsFrancisco D. Rodriguez and Rafael Covenas6. Substance P in the cardiovascular systemMagdalena Chottova Dvorakova and Shashank Pandey7. Substance P in lower urinary tract function and dysfunctionMitsuharu Yoshiyama8. Role of the substance P in learning and memoryNatalia Favila and Paul G. Overton9. Substance P in nausea and vomitingPaul L.R. Andrews, John A. Rudd, and Gareth J. Sanger10. Substance P in the central control of respirationNicholas J. Burgraff and Jan-Marino Ramirez11. Substance P in bone metabolismTanja Niedermair and Susanne Grassel12. Life without substance P: The naked mole ratAishi Zhao, Jiwon Lee, Weronika Gryszkiewicz, and Thomas J. Park13. Substance P in inflammationSophie E. Sipprell and Ian Marriott14. Substance P in oxidative stressSeyed Isaac Hashemy and Safieh Ebrahimi15. Substance P in painRobert Vink16. Substance P in cancerMiguel Munoz, Marisa Rosso, Riffat Mehboob, and Francisco Esteban17. Substance P in cardiac dysfunctionScott P. Levick and Alexander Widiapradja18. Substance P in neurotraumaRebecca George, Justin Krieg, and Frances Corrigan19. Substance P in strokeAnnabel Sorby-Adams20. Substance P in Alzheimer's and Parkinson's diseaseSeverini Cinzia21. Substance P receptor antagonists for major depressive disorderNadia M.J. Rupniak and Mark S. Kramer22 From a putative antidepressant to a validated mouse model of ADHD via NK1 receptorsS.C. Stanford23. Substance P in stress and anxietyKarl Ebner and Nicolas Singewald24. Substance P-neurokinin 1 receptor pathway in musculoskeletal disordersBrendan A. Hilliard and Mary F. Barbe25. Substance P and sudden infant death syndrome (SIDS)F. Bright, Robert Vink, and R.W. Byard26. Immunobiology and pharmacology of neuropeptide substance PEhsan Aslam, Asina Gijasi, Caroline Perner, Rob van Wijk, Anne-Grete Martson, Gerard J.P. van Westen, Ilze Bot, Laura H. Heitman, and Alireza Mashaghi27. Substance P in viral diseases-Especially coronavirus diseaseRiffat Mehboob, Mariam Hashim, and Miguel Munoz28. Substance P: Perspectives and future directionsRobert Vink
