Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.
- Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field
- Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease
- Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 250 illustrations (50 in full color)
Dateigröße
ISBN-13
978-0-323-85358-3 (9780323853583)
Schweitzer Klassifikation
Part 1: Modern tools and concepts in toxicology testing1. Mixture toxicity evaluation in modern toxicology2. Alternative methods and their role in modern toxicology3. The exposome-a new paradigm for nonanimal toxicology and integrated risk assessment4. In silico toxicology, a robust approach for decision-making in the context of next-generation risk assessment5. Safety science in the 21st century-a scientific revolution in its making6. Chemobrain
Part 2: Methods and toxicity models in toxicology7. "Predictive in silico toxicology." An update on modern approaches and a critical analysis of its strong and weak points8. Analytical strategies to study the gut microbiome in toxicology9. Behavioral endpoints in adult and developmental neurotoxicity: the case of organophosphate pesticides10. Nuclear factor erythroid 2-related factor 2-mediated antioxidant response as an indicator of oxidative stress11. The potential of complex in vitro models in pharmaceutical toxicology
Part 3: New insights in risk assessment12. Health-based exposure limits and toxicology in pharmaceutical industry13. The hormetic dose response: implications for risk assessment14. Endocrine disruption and human health risk assessment in light of real-life risk simulation15. Toxicity data as the basis for acute and short-term emergency exposure guidance16. Renal mitochondria as sentinels for exposures to environmental toxicants and nephrotoxic drugs
Part 4: Clinical biomarkers updates17. Updates on current biomarkers in toxicology18. The role of extracellular matrix in allergic contact dermatitis pathogenesis19. Review of current neurotoxicology issues20. Modern aspects of immunotoxicology21. Toxicology of neurodegenerative diseases22. Toxicogenetics-Pharmacogenetics: genetic variability profiling for xenobiotic response heterogeneity23. Current and emerging concepts of cardiotoxicity24. Metabolomics: diagnostic and therapeutic applications in clinical medicine and pharmacology25. Metabolomics methodology and workflow: challenges and future prospects26. Telomere length: associations with nutrients and xenobiotics
Part 5: Epidemiology and public health toxicology issues27. Dismissing the use of P-values and statistical significance testing in scientific research: new methodological perspectives in toxicology and risk assessment28. Modern approaches for the assessment of human exposure to dietary mycotoxins29. Tobacco toxicity and regulatory science30. Dethroning the crown. From the kinetics and dynamics of COVID-19 diagnosis to the promising treatments31. Toxicology issues related to COVID-19 outbreak32. Risk assessment for heat stress during work and leisure
Part 6: Pharmaceuticals and nutraceuticals toxicology updates33. Polyphenols: the hallmark of endothelial dysfunction combatants34. Effect of diet, pharmaceuticals, and environmental toxicants on gut microbiota imbalance and increased intestinal membrane permeability35. Hydrogen sulfide: a shifting paradigm36. Redox biomarkers in toxicology and nutrition: the social link37. Safety profile of plants and phytoconstituents used in traditional medicine worldwide
Part 7: Toxicology of biomaterials and nanomaterials38. Epigenetic mechanisms in nanomaterial toxicity39. Predictive nanotoxicology: from nanotoxicity to nanosafety of select and commonly used nanomaterials40. The toxicological effects of titanium dioxide nanoparticles on marine microalgae41. Aquatic nanotoxicology: reference species and omics technologies Part 8: Special topics in toxicology42. Toxicity of arsenicals in diseases: friend or foe?43. Toxicity of psychedelic drugs44. Immunotoxicity of pesticides: current knowledge and perspectives45. Glyphosate-based herbicides: evidence of immune-endocrine alteration46. Ciguatera toxins: toxicity and food safety47. Cannabinoids and psychosis: current challenges of mechanistic toxicology48. Electronic cigarettes as a harm reduction concept for public health