Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
- Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders
- Covers key methodological processes that are important in personalized medicine
- Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area
- Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-443-23803-1 (9780443238031)
Schweitzer Klassifikation
Section I. Overview1. Epigenetics of Personalized MedicineSection II. Epigenetic variations Among Individuals2. Interindividual Variability of DNA Methylation3. Differences in Histone Modifications Between Individuals4. Individual Noncoding RNA Variations5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation6. Limitations of Personalized Epigenetic Variation ComparisonsSection III. Technologies for Personalized Epigenetics7. Personalized Epigenetics Technologies8. Computational Methods in EpigeneticsSection IV. Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine9. Epigenetic Biomarkers in Personalized Medicine10. Epigenetic 'Fingerprint'11. Epigenetics of Personalized ToxicologySection V. Environmental Personalized Epigenetics12. Environmental Contaminants and Their Relationship to the Epigenome13. Nutriepigenomics: Personalized Nutrition Meets EpigeneticsSection VI. Pharmacology and Drug Development of Personalized Epigenetics14. Personalized Pharmacoepigenomics15. Epigenetics of Personalized Nanomedicine16. Personalized Medicine and Epigenetic Drug DevelopmentSection VII. Personalized Epigenetics of Disorders and Disease Management17. Understanding Interindividual Epigenetic Variations in Obesity and Its Management18. Personalized Epigenetic Management of Diabetes19. Epigenetics and Personalized Pain Management20. Epigenetic Modification of miRNAs in Cancer21. Epigenetics and Chemoresistance: A Personalized Approach to Cancer Therapy22. Personalized Epigenetics and Neurological Disorders23. Managing Autoimmune Disorders through Personalized Epigenetic Approaches24. Cardiovascular Diseases and Personalized EpigeneticsSection VIII. Challenges and Future Directions25. Future Challenges and Prospects for Personalized Epigenetics
