T Cell Metabolism and Cancer Immunotherapy

T Cell Metabolism and Cancer Immunotherapy investigates the cellular regulation of T-cell immunity and tolerance. Most effort is being expended to develop and optimize strategies for utilizing highly reactive T lymphocytes for cell-based therapies. Because of the plasticity and potentially unlimited capacity for self-renewal, stem cell-derived T lymphocytes have great potential in the treatment of diseases including cancer.¿ Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy.¿ By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity. Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy - Provides a summary of the current state-of-the-art, creating a valuable foundation for both established researchers and newcomers/students in the field in cancer immunotherapies - Focuses on the investigation of cellular regulation of T-cell immunity and tolerance - Defines the precise role and mechanism of T cell metabolism in modulating T cells and T cell-mediated immunity