IntroductionBurkhard Poeggeler 1. Therapeutic potential of genome editing tools in neurodegenerative diseasesAnkur Kumar, Nandigam Pardhipa, Sachin G. Swami, Vibha Dwivedi and Anand K. Singh2. Genetic and molecular basis of neurodegenerative diseasesSunanda Yogi, Anjali Sangeeth, Anuradha Venkatakrishnan Chimata, Radhika Padma and Amit Singh3. Genome editing tools: principles, structures, and mechanismsRayees Ahmad Naik, Mehak Naseer Mir, Roshni Rajpoot, Sonalika Singh, Kusum Singh and Sandeep Kumar Singh4. Advances in CRISPER/Cas system and genome editing technologies for the treatment of neurodegenerative diseasesShailendra Kumar Mishra, Hung-Ming Chang, Ahmad A. Obaid and Sandeep Kumar Singh5. Use of CRISPR system in genetic screening to detect neurodegenerative diseaseKoyel Kar6. Epigenetic manipulation and gene regulation using the CRISPR/Cas system for neurodegenerative diseasesJosephine Esposto7. Transgene delivery system: viral, nonviral, and other methods for central nervous systemBhupender Sahu, Bibhudendu Behera and Umesh Kumar8. Gene therapies for neurodegenerative disease: current knowledge and challengesBhumi Arora, Sakshi Garg, Aditya Shrivastav, Mrinalini Sharma, Bhupender Sahu and Umesh Kumar9. Gene therapy under clinical trials for neurodegenerative diseasesBhupender Sahu, Lakshita Tyagi, Prshant Tyagi and Umesh Kumar10. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeuticsBurkhard Poeggeler