Bioreactor Design Concepts for Viral Vaccine Production covers a range of interdisciplinary chapters from the engineering perspective of bioreactor design to the biotechnological perspectives of vector design for vaccine development. The book covers bioreactor concepts such as static systems, single-use systems, stirred tanks, perfusion, wave and packed-beds. It reviews options for efficient and economical production of human vaccines and discusses basic factors relevant for viral antigen production in mammalian cells, avian cells, and insect cells. This book will be a great resource for those interested in implemented novel bioreactor design or experimental schemes towards intensified or/and enhanced vaccine production.
- Covers the fundamentals of bioreactor designs
- Provides strategies for designing a successful vector-based vaccine
- Discusses the applications of biological kinetics, thermodynamics and basic substrate requirements for viral vaccine production
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-443-15379-2 (9780443153792)
Schweitzer Klassifikation
1. Introduction: Understanding of Bioreactor2. Stoichiometry for Biochemical Process3. Biochemical aspects of bioreactor operation4. Scale-Up of Cell-Culture Bioreactors5. Application of modeling in bioreactor design and analysis6. Vaccine and Vaccine types7. Development a new vaccine at lab scale8. Animal cell cultivation in bioreactor9. Characterization of cultured animal cells10. Bioreactor design for vaccine production11. Advance development in membranes for virus producing bioreactors12. Downstream Processing for vaccines13. Vaccine against RNA viruses14. Vaccine against DNA viruses15. Development of a bioprocess for rotavirus vaccine16. Single-use fixed bed bioreactor for scalable virus production17. Production of rabies vaccine in the large-scale bioreactor18. Bioreactor for hepatitis C virus vaccine19. Bioreactor for Vero cell for the production of viral vector and vaccines.20. Titration and dose calculation of the vaccine stock21. Bioreactor process development for DNA vaccine production
