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Modern life as we know it is in large part due to the polymers that are all around us - from plastics and petroleum, to cosmetics and food, to artificial limbs and adhesives. What we think of less often are the polymers that make life possible. Biological polymers-biopolymers-fill the insides of nearly all biological cells as well as the interstitial space that surrounds them. Networks of these ubiquitous polymers have been the subject of fervent investigation in fields as diverse as cellular and molecular biology, polymer physics, materials science, and chemical engineering, to shed light on the governing principles underlying soft and active matter systems, biological processes, and materials design optimization. This book has been written through the lens of all of these unique perspectives and goals of the rich interdisciplinary community.
This text provides an overview of biopolymer networks written for an interdisciplinary audience from undergraduates to seasoned principal investigators. It opens with an introduction to biopolymers and their networks, followed by an overview of important polymer physics theories and concepts, experimental tools to measure network properties, and computational analysis techniques to characterize and interpret data. The book follows with a description of model biopolymer networks-from design to rheology-before embarking on a discussion of novel network designs and their emergent physical properties, including topologically-novel polymers, composites, active matter, and liquid-liquid phase separation. The book closes with a community-led perspective on key open questions and grand challenges, and how we may come together to advance understanding of biopolymer networks and their utility in diverse applications.
Rae M Robertson-Anderson is Professor of Physics and Biophysics and Associate Provost for Engaged Scholarship at the University of San Diego, where she has established an internationally recognized research program to elucidate macromolecular dynamics and microscale mechanics of bio-inspired soft and active matter systems. Robertson-Anderson is a leading expert in the design of novel microrheology methods and complex biopolymer composites to address critical questions in soft matter physics and cell biology. She is equally passionate about promoting and advancing undergraduate research and education, and building community among diverse scientists and with the general public. Robertson-Anderson has been awarded over $5M in grants to support her research, and her 74 publications feature 85 undergraduate co-authors.
Part I Let's Get Started
1 Introduction to biopolymers and networks
Part II Making Sense and Measuring
2 Polymer physics for everyone
3 Measuring mechanics, dynamics, and structure
4 Analysis methods, algorithms, and deliverables
5 Biopolymer network design, dynamics, and mechanics
Part III Beyond the Basics - Novel and Complex Networks
6 Networks of topologically-novel biopolymers
7 Biopolymer composites, blends, and crowding
Part IV Spatiotemporal Heterogeneity: From Active Matter to Coacervates
8 Active, responsive, and reconfigurable networks
9 Self-assembly and phase separation
Part V What now?
10 Past, present, and future: perspectives from the community
Glossary
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