Pituitary Adenylate Cyclase Activating Polypeptide - PACAP

Part 1. Evolutionary Aspects of PACAP.- 1. Molecular evolution of Pituitary adenylyl cyclase-activating polypeptide subfamily and cognate receptor subfamily.- 2. Occurrence, distribution and physiological function of pituitary adenylyl cyclase-activating polypeptide in invertebrates species.- 3. PACAP-like compounds of earthworms: identification and putative functions from embryonic development to brain regeneration.- 4. PACAP and learning in invertebrates.- Part 2. Effects of PACAP in Neuronal Development.- 5. PACAP and Neural Progenitor cells.- 6. PACAP and neural development.- 7. PACAP modulates distinct neuronal components to induce cell-specific plasticity at central and autonomic synapses.- Part 3. PACAP Receptors and Signalling.- 8. The pharmacophoric determinants of PACAP.- 9. PACAP-derived carriers: mechanisms and applications.- 10. Effects and development of TAT-tagged PACAP/VIP and related peptides.- Part 4. Presence and Physiological Functions of PACAP in Diverse Systems.-11. Presence and role of PACAP in endocrine glands of mammals.- 12.Distribution of PACAP in the mammalian nervous system.- 13. Multiple mechanisms contribute to the PAC1 modulation of parasympathetic cardiac neuron excitability.- 14. PACAP in the circadian timing system - learning from knockout models.- 15. The role of PACAP in the regulation of body temperature.- Part 5. Presence and Functions of PACAP in the Gastrointestinal and Urinary Tracts.- 16. PACAP Regulation of gastrointestinal function and obesity.- 17. Protective intestinal effects of pituitary adenylate cyclase activating polypeptide.- 18. Renoprotective effects of pituitary adenylate cyclase-activating polypeptide 38 (PACAP38).- 19. Neuroplasticity of PACAP expression and function in micturition reflex pathways.- Part 6. Functions of PACAP in the Skeletal System.- 20. Role of PACAP and VIP signalling inregulation of chondrogenesis and osteogenesis.- 21. Role of PACAP/VIP in bone and joint physiology and pathophysiology.-Part 7. PACAP in the Regulation of the Reproductive System.- 22. Role of PACAP and its PACAP type I receptor in the central control of reproductive hormones.- 23. Occurrence and functions of PACAP in the placenta.- 24. PACAP in the reproductive system.- Part 8. PACAP in Biological Barriers and Barrier-Forming Cells.- 25. Transport of Pituitary Adenylate Cyclase Activating Polypeptide across the Blood-brain Barrier: Consequences for Disease States and Therapeutic Effects.- 26. Effects of PACAP on biological barriers.- 27. Role of PACAP in astrocytes and astrocytic tumors.- 28. Multiple actions of pituitary adenylate cyclase-activating polypeptide (PACAP) in Schwann cell biology.- Part 9. PACAP in Sensory Systems.- 29. Sniffing Out a Role for PACAP in the Olfactory System.- 30. Retinoprotective effects of PACAP.- 31. Pituitary adenylate cyclase activating polypeptide in the auditory system.- Part 10. Neuroprotective effects of PACAP.- 32. PACAP signaling in neuroprotection.- 33. PACAP expression and plasticity in the peripheral nervous system.- 34. The neuropeptide PACAP, a potent disease modifier candidate for brain stroke treatment.- Part 11. PACAP in the Pathomechanism of Migraine and Pain.- 35. Pituitary adenylate cyclase activating polypeptide (PACAP) in migraine pathophysiology.- 36. PACAP regulation of vascular tone: differential mechanism among vascular beds.- 37. PACAP circuits mediating the sensory and behavioral consequences of pain.- Part 12. Role of PACAP in Inflammatory Processes.- 38. PACAP modulation of CNS and peripheral inflammation.- 39. PACAP regulation of inflammatory and free radical networks in neuronal and non-neuronal diseases.- 40. Immunobiology of the pituitary adenylate cyclase-activating peptide.- Part 13. PACAP in Stress and Mood Disorders.- 41. PACAPergic synaptic signaling and circuitry mediating mammalian responses to psychogenic and systemic stressors.- 42. Using PACAP heterozygous mice as models of the three hit theory of depression.- 43. PACAP and Depression.- 44. Implications of PACAP signaling in psychiatric disorders.- 45. Mechanisms of PACAP in PTSD and stress-related disorders in humans.- 46. PACAP, VIP and ADNP: autism and schizophrenia.- Part 14. Clinical Relations of PACAP.- 47. PACAP and cancer.- 48. PACAP as a potential biomarker - alterations of PACAP levels in human physiological and pathological conditions.- 49. Examination of PACAP during lactation.- Index.