Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders

Contributors About the editors Preface UDINE 2023 Objective of this volume Highlights I General introduction1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgerySignori Davide, Mattias Carlström, Lorenzo Berra, and Rezoagli EmanueleAbbreviations Introduction Pathophysiology of CSA-AKI and NO dysregulation Renal vasoconstriction Direct free-hemoglobin and catalytic iron injury Ischemiaereperfusion injury Conclusions Conflict of interest statement Acknowledgments References II Nitric oxide and cancer2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancerArduino A. Mangoni, Lashika Weerakoon, Vinitha N. Ragavan, Natalia Jarzebska, Roman N. Rodionov, and Sara TommasiAbbreviations Introduction Vasculogenic mimicry: Pathogenesis and clinical significance Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry General considerations Conflict of interest statement ReferencesIII Nitric oxide reactions in the cells and models to check its biological properties3. Decoding S-nitrosylation: Theoretical aspects and analytical approachesGianmarco Matrullo, Chiara Pecorari, and Giuseppe FilomeniAbbreviations Introduction NO signaling Nitric oxide in physiology and pathology S-nitrosylation detection: Approaches and challenges Conclusion Conflict of interest Acknowledgments References 4. Preclinical models to assess the pharmacological properties of NO derivativesLucia Morbidelli and Valerio CicconeAbbreviations From preclinical to clinical trials of drugs Cell-based in vitro pharmacological screening and safety assessment Ex vivo experiments In vivo experiments to assess efficacy and safety of NO derivatives Conclusions Acknowledgements References IVNitric oxide and neurodegeneration5. Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegenerationJennifer Cale, Tracy D. Farr, Sebastien Serres, and Joern R. SteinertAbbreviations Introduction Neurovascular oxidative and nitrergic stress Redox stress in the vascular, neuronal, and astrocytic compartments Therapeutic targets of NO signaling Conclusions Acknowledgments References V Nitric oxide and therapeutics6. Role of nitric oxide in gemcitabine resistance in pancreatic cancer cellsMariachiara Gani, Eros Di Giorgio, Raffaella Picco, Luigi E. Xodo, and Valentina RapozziAbbreviations Introduction Acknowledgments References Further reading 7. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implicationsInesa Navasardyan and Benjamin BonavidaAbbreviations Introduction Treatment of GBM NO production and its biological process Role of the INOS/NO pathway in GBM NO-targeted therapies in GBM Discussion Perspectives and future directions Acknowledgments References 8. Nitric oxide donating systems and their potential in shaping tumor immunoregulationGreta VarchiIntroduction The tumor microenvironment The enigmatic dual nature of nitric oxide in cancer Nitric oxide donors Nitric oxide donors and the immune system Conclusions and future directions References 9. Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancerEros Di Giorgio, Valentina Rapozzi, and Luigi E. XodoAbbreviations Introduction NOS2 structure and function NOS2 and cancer Transcription factors activating NOS2 expression NRF2 controls the expression of NOS2 RF2 binds to a distal enhancer of NOS2 PDAC-spheroids formation depends on NOS2: Therapeutic implications Concluding remarks Conflict of interest References Further Reading 10.