The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches.
- Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations
- Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics
- Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-12-819183-5 (9780128191835)
Schweitzer Klassifikation
1. Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC)2. The neurodevelopmental basis of Bipolar Disorder: Mechanisms and Implications3. The neuroprogressive nature of Bipolar Disorder: Mechanisms and Implications4. Immune mechanisms in Bipolar Disorder: evidence and implications5. Mitochondrial pathways in Bipolar Disorder: mechanisms and implications6. Neuro-oxidative and neuro-nitrosative mechanisms in bipolar disorder: evidence and implications7. Mechanisms underpinning neurocognitive dysfunction in bipolar disorder8. The evolution of animal models for bipolar disorder9. Alteration in Circadian rhythms in bipolar disorder: mechanisms and implications10. The genetics of bipolar disorder11. Pharmacogenomics of bipolar disorder12. Blood-brain barrier dysfunction as a pathophysiological mechanism of bipolar disorder13. Induced Pluripotent stem cells as tools for the investigation of the neurobiology of bipolar disorder14. Bipolar disorder as a gliopathy15. Molecular Imaging findings in Bipolar disorder16. Structural and functional neuroimaging findings in bipolar disorder17. Epigenetic mechanisms of bipolar disorder18. Bipolar disorder and cardiovascular dysfunction: mechanisms and implications19. At-risk mental states for bipolar disorder20. Stress, allostatic load and bipolar disorder: mechanisms and implications21. Bipolar disorder, obesity and metabolic disturbances: mechanisms and implications22. The gut-brain axis in bipolar disorder23. The hypothalamic-pituitary-adrenal axis in bipolar disorder24. Disturbed neuroplasticity pathways in bipolar disorder: mechanisms and implications25. Aberrations in intracellular signaling pathways in bipolar disorder26. The impact of early-life stress in the development and course of bipolar disorder: mechanisms and implications27. Bipolar disorder and accelerated aging: mechanisms and implications28. Suicidal behaviors in bipolar disorder29. Pediatric bipolar disorder30. Late-life bipolar disorder31. Biomarkers for Bipolar Disorder32. The mechanisms of action of lithium in bipolar disorder33. Is there a biosignature for lithium response in bipolar disorder? Evidence and implications34. Exercise as a treatment for bipolar disorder35. Non-invasive neuromodulatory approaches for bipolar disorder36. Novel therapeutic drug targets for bipolar disorder37. The treatment of bipolar disorder in the era of precision psychiatry: challenges and opportunities
