Mouse Models for Drug Discovery

Genetically Defined Strains in Drug Development and Toxicity Testing.- Simple, Efficient CRISPR-Cas9 Mediated Gene Editing in Mice: Strategies and Methods.- Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice.- Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.- Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.- A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics.- Germ-Free Mice Model for Studying Host-Microbial Interactions.- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans.- Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery.- Cholesterol Absorption and Metabolism.- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.- Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research.- Murine Model for Colitis-Associated Cancer of the Colon.- Mouse Models for Studying Depression-Like States and Antidepressant Drugs.- Experimental Models of Anxiety for Drug Discovery and Brain Research.- Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders.- Better Utilization of Mouse Models of Neurodegenerative Diseases in Preclinical Studies: From the Bench to the Clinic.- Neuromuscular Disease Models and Analysis.- Brightfield Imaging and Optical Coherence Tomography of the Mouse Posterior Eye.- Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis.