Neurodegenerative Diseases

Table of Contents List of Contributors 1 Neurodegenerative Diseases: Evolving Unifying Principles Jeffrey Cummings and Jagan Pillai 2 Neurodegenerative Diseases as Protein Misfolding Disorders Tomohiro Nakamura and Stuart A. Lipton 3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny 4 Neuroinflammation and Neurodegenerative Diseases Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb 5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding Jiri Safar 6 Neuropsychiatric Features Across Neurodegenerative Diseases Claudia R. Padilla and Mario F. Mendez 7 Brain Circuits: Pathway for NDD William Seeley 8 Fluid Biomarkers Indicative of Neurodegenerative Diseases Henrik Zetterberg and Jonathan M. Schott 9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features Jagan Pillai 10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms Lynn M. Bekris and James B. Leverenz 11 An Epigenetics Perspective on Diseases of the Central Nervous System Diego Mastroeni 12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases Andrew B. Knot and Ella Bossy-Wetzel 13 Cell Culture and iPS Cells and Neurodegenerative Diseases Roxana Nat and Andreas Eigentler 14 Animal Models of Neurodegenerative Diseases David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla 15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases Peng Lei, Scott Ayton, and Ashley I. Bush 16 Disease modifying therapies in neurodegenerative disorders Janelle Drouin-Ouellet and Roger A. Barker 17 Immunotherapy for Neurodegenerative Disorders David Morgan 18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles Jeffrey Cummings and Kate Zhong 19 Conclusions on Neurodegenerative Disorders: Unifying Principles Jagan Pillai and Jeffrey Cummings Index