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Understand the fundamentals of human risk assessment with this introduction and reference
Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process.
Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work.
Readers of the second edition of Human and Ecological Risk Assessment will also find:
Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.
Dennis J. Paustenbach, PhD, has more than 35 years experience in the field of risk assessment and has conducted as many as 1000 risk assessments personally. He was the founder of ChemRisk and has published extensively on risk assessment and related subjects.
List of Contributors ix
Foreword to the Third Edition xv
Foreword to the Second Edition xix
Foreword to the First Edition xxiii
Preface xxv
About the Editor xxix
Volume 1
Section A Theory: Human Health Assessment 1
1 Primer on Human and Environmental Risk Assessment 3 Dennis J. Paustenbach, Blake T. Langenbach, and Richard J. Wenning
2 Hazard Identification (Humans) 71 Dennis J. Paustenbach and Richard J. Wenning
3 Hazard Identification (Environmental) 91 Richard J. Wenning and Dennis J. Paustenbach
4 Dose-Response Assessment (Cancer and Non-Cancer) 125 Dennis J. Paustenbach and Louis A. Cox Jr
5 Exposure Assessment 157 Dennis J. Paustenbach, Amy K. Madl, and Andrey Massarsky
6 Risk Characterization 263 Pamela R.D. Williams and Dennis J. Paustenbach
Section B Case Studies of Human Health Hazards of Various Contaminated Media 333
B.1 Case Studies Involving Contaminated Water 335
7 Per- and Polyfluoroalkyl Substances (PFAS) in Drinking Water: A Retrospective Case Series with Risk Assessments 337 Daniel G. Kougias, Allison Killius, Justin Collins, Eric Russman, and Mark Maddaloni
B.2 Case Studies Involving Contaminated Soils 397
8 Quantitative Risk Assessment for Synthetic Biology: A Case Study of Plastics Degradation in Municipal Landfill 399 Anna Ulanova, Ping Gong, Benjamin D. Trump, Christopher L. Cummings, and Igor Linkov
9 Dose Reconstructions for Radionuclides: Case Study Involving Hunters Point Naval Shipyard (HPNS), California 415 David Brew, Ayla Pavelka, Jack Buddenbaum, Michael E. Stevens, Dennis J. Paustenbach, and Robert D. Gibbons
B.3 Case Studies Involving Air Contaminants 469
10 Mathematical Modeling of Environmental and Occupational Exposure 471 David H. Collins, Nitheesh George, and James Brett
B.4 Case Studies Involving Consumer Products 497
11 Health Risk Assessment of Consumer Products: Case Studies of DEHP Exposure From Disposable Plastic Packaging and Formaldehyde Exposure From a Residential Couch 499 Rachel N. Hirani, Jennifer L. Bare, and Claire Mathis
12 Health Risks of Fungi in the Built Environment 525 Jeffrey Hicks and Ryan Lewis
13 A Risk Assessment of Cosmetic Talc for the Development of Mesothelioma and Ovarian Cancer 541 A. Michael Ierardi, Amanda Burns, Ania Urban, and Brent Finley
14 Proposition 65 and Exposure Assessment Methods 571 Renee M. Kalmes, Melinda T. Donnell, Keith Morris-Schaffer, and Carolyn G. Scrafford
15 Latest Developments in the Risk Assessment of Nanomaterials: A Framework for Advanced Materials and Emerging Technologies 583 Jo Anne Shatkin, James Ede, and Kimberly Ong
Volume 2
B.5 Case Studies Involving Occupational Exposure 609
16 Assessment of Human Health Risks Associated with Changing Clothes and Handling Work Uniforms Containing Foundry Dust 611 Jason T. Lotter, Tyler V. Ferracini, Benjamin Roberts, and Thomas J. Slavin
17 A Review of Take-Home Exposure and Risk Associated with the Handling of Clothing Contaminated with Asbestos 643 Tyler V. Ferracini and Jennifer Sahmel
18 Case Study: Occupational Use, Exposures, and Environmental Chamber Studies of Human Eye and Respiratory Irritation Responses for a Peracetic Acid-based Hospital Surface Disinfectant 671 B.D. Kerger , A.E. Loccisano, and P. Dalton
B.6 Methods for Conducting Exposure Assessments for Children 717
19 Children's Health and Exposure to Chemicals in the Natural and Built Environment 719 Susan Goldhaber , Rachel Slover , Ashley Mullikin , Nicolle Tulve, and Elaine A. Cohen Hubal
20 Assessing Children's Exposure to Contaminants in House Dust: A Case Study of Flame Retardants 747 Nicole M. DeLuca and Elaine A. Cohen Hubal
B.7 Assessment of Tainted Foods 779
21 Microbial Risk Assessment 781 Antony D. G. Jones
Section C Theory: Ecological Risk Assessment 833
22 Fundamentals of Ecological Risk Assessment 835 Richard J. Wenning
23 Application of Weight of Evidence in Ecological Risk Assessment 865 Katherine Coady , Mary Sorensen , Thomas Steeger , and Paige Leitman
Section D Case Studies in Environmental and Aquatic Risk Assessment 897
24 Case Study - Screening Level Ecological Risk Assessment of Residual Soil Contamination at a Former Munitions Disposal Landfill 899 Richard J. Wenning
25 Assessing Risks to Wildlife from Exposures to Chemicals 917 Bradley E. Sample, Mark S. Johnson, and Dwayne R.J. Moore
Section E Important Topics Related to Environment Assessment 975
26 Emerging Frameworks and Tools for Environmental Risk Assessment 977 Charles A. Menzie, Taryn Horr , Roxolana Kashuba, Michael W. Kierski , Konrad J. Kulacki ,Margaret E. McArdle, Sean F. Ryan, and Alicia A. Taylor
27 Tiered Environmental Causal Analysis 1009 Charles A. Menzie, Michael W. Kierski, William Goodfellow , and Roxolana Kashuba
Section F Risk Assessment Policy and Practice in Countries Outside the United States 1031
28 Risk Scoring Methods for Ranking Hazards to Human Health and Environment - Contaminated Sites as a Case Study 1033 Victor Gabriel Kabay
29 Australian Case Studies Involving Exposure to PFOS 1051 Tarah G. Hagen, Giorgio De Nola, Anthony Lane, and Jill Woodworth
30 How Risk Assessments Are Conducted in Germany; Including a Case Study 1091 Helmut Greim
Section G Carcinogens in Perspective 1101
31 Misconceptions about the Causes of Cancer 1103 Lois Swirsky Gold, Bruce N. Ames, and Thomas H. Slone
Section H Research Methods, Economics, and Risk Communication 1131
32 Evidence-Based Methods in Toxicology: Systematic Review and Systematic Evidence Mapping 1133 Daniele Wikoff and Seneca Fitch
33 Risk Assessment and Regulatory Impact Analysis 1149 Susan E. Dudley and George M. Gray
34 Co-Benefits, Countervailing Risks, and Cost-Benefit Analysis 1167 John D. Graham and Jonathan B. Wiener
35 Communicating Risks 1189 Hugh D. Walpole and Robyn S. Wilson
Index 1203
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