Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.
Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.
- Presents the fundamentals of the complex interplay of cells with biomaterials in musculoskeletal tissue engineering
- Includes coverage of stem cells and cell-based therapies, in vitro and in vivo models, nanotechnology, bioprinting, computational modeling, regulatory and clinical translation, and much more
- Written by global leaders in the field
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-97262-8 (9780323972628)
Schweitzer Klassifikation
Section 1: Fundamentals of cell-biomaterials interactions1. Introduction2. Fundamentals and mechanisms3. Cellular signaling processes4. Cell-protein interactions5. The microenvironment: Recreate the ECM6. Surface modifications - topography, porosity7. Chemotaxis: Soluble morphogens and Growth factors8. Cell-biomaterials: Vascularization9. Cell-biomaterials in Immunomodulation10. Mechanobiology regulation11. Electrical/Magnetic stimulation
Section 2: Multiscale design, structure/function and processing technologies12. Introduction13. Design of polymeric biomaterials at multiscale14. Design of Calcium phosphates cements: Structure/function15. Biomimetic micro-/nano- scales design16. Cells-biomaterials structure-function at different length scales17. Computational modelling involved in multiscale design18. Hydrogel systems design: Structure/function19. Scaffolding design and structure/function: Electrospinning20. Scaffolding design and structure/function: Advanced manufacturing21. Scaffolding design and structure/function: Bioprinting22. Dynamic models for investigating structure/function of biomaterials: Bioreactors23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics24. Complex in vitro models for studying cell-biomaterials interactions25. In vivo animal models 26. Regulatory and clinical translation
