TRPs as Special Cell Sensors: Temperature Sensing with TRPs.- TRPs in Mechano-sensing and Volume Regulation.- TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters).- Photosensitive TRPs.- TRPs in Taste and Chemesthesis.- Pain.- TRPs in Hearing.- TRPs in Olfaction.- TRP Structure.- Pain.- TRPs in Hearing.- TRP in Olfaction.- General Topics: Evolutionary Conserved, Multitasking TRP Channels-lessons From Worms and Flies.- TRPs as Novel Drug Targets.- TRPs in Endocrinology.- TRPs Modulation by Toxins.- TRPs and Phosphoinositides.- TRPs Modulation by Natural Compounds.- What do we Really Know and What do we Need to Know: Controversies, Perspectives, Surprises.