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All-new edition of a classic textbook bridging the gap between human biology and clinical practice
The Biology of Disease provides a comprehensive overview of the principles of the disease process. Building on the success of previous editions, this all-new Third Edition reflects the unprecedented challenges that the global community now faces in the field, as well as advances in the basic sciences of cell biology, immunology, and the molecular mechanisms of disease, with all chapters extensively modified to ensure that they remain at the cutting edge of current knowledge.
Each section is followed by case studies which bridge the gap between theory and clinical practice. This Third Edition includes 72 case studies in total, of which 34 are new. All diagrams and figures have been updated to present the most relevant information at a glance, and a new companion website with more than 500 multiple choice questions in two difficulty levels has been made available.
Written by three highly qualified academics with significant experience in the field, The Biology of Disease includes information on:
The Biology of Disease is an essential textbook resource for medical students with a focus in physiology, pathophysiology, or pharmacology, along with undergraduate students in biomedical science, biomedicine, medical biochemistry, and human biology.
Prof. Paul G. Murray, Department of Pathology, Royal College of Surgeons in Ireland-Medical, University of Bahrain. Professor of Molecular Pathology at University of Limerick, Ireland, and Honorary Professor, University of Birmingham, United Kingdom.
Dr. Simon J. Dunmore, Honorary Clinical Senior Lecturer, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen; Honorary Lecturer, Cardiovascular Sciences, School of Medicine, University of Edinburgh; NHS Scotland (Grampian).
Dr. Shantha Perera, Visiting Senior Lecturer, School of Life Sciences, University of Wolverhampton, United Kingdom.
PART 1: BASIC PRINCIPLES OF DISEASE 1. The Nature of Disease 2. Principles of Epidemiology
PART 2: CELL REPRODUCTION, INJURY AND DEATH 3. Cell Reproduction, Injury and Death
PART 3: INFECTIOUS DISEASES 4. Infectious Diseases Case Studies 1 to 13
PART 4: INFLAMMATION AND DISORDERS OF IMMUNITY 5. Inflammation and Repair 6. Disorders of the Immune System Case Studies 14 to 33
PART 5: DISORDERS OF BLOOD AND BLOOD VESSELS 7. Anaemia 8. Disorders of Haemostasis 9. Vascular Disorders Case Studies 34 to 40
PART 6: GENETIC DISORDERS 10. Genetic Disorders Case Studies 41 to 50
PART 7: NEOPLASIA 11. Neoplasia Case Studies 51 to 68
PART 8: OBESITY, DIABETES AND ENVIRONMENTAL DISEASES 12. Nutritional Disorders and Obesity 13. Diabetes 14. Toxicology and Environmental Diseases Case Studies 69 to 72
APPENDIX Reference ranges in haematology Reference ranges in clinical biochemistry
Numbers in [ ] denote authors of chapter or case study.
Ashraf Albishtawi Medical Student, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [9,CS19,CS40,CS50]
Fatima AlHashimi Consultant Histopathologist, King Hamad University Hospital, Bahrain, and Senior Clinical Lecturer, Royal College of Surgeons in Ireland - Medical University of Bahrain [CS31,CS32]
Mohamed AlKhaja Consultant Neurologist, Epileptologist and Clinical Neurophysiologist, King Hamad University Hospital, Bahrain [CS15,CS25,CS56]
Jumana Turky K. Alrujaib Medical Student, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS15,CS25]
Rawaa Alsayegh Clinical Educator in Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [9,CS10,CS12,CS13,CS14,CS18,CS20, CS22,CS33,CS36,CS40,CS54,CS55,CS57,CS58, CS61,CS63,CS67,CS68]
Raja H. Alyusuf Consultant Pathologist, Department of Pathology, Salmaniya Medical Complex, Kingdom of Bahrain and Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS22]
Stephen Atkin Head, School of Postgraduate Studies and Research, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [13,CS70,CS71,CS72]
Shivani Bailey Consultant in Paediatric Neuro-oncology, Birmingham Children's Hospital and Senior Clinical Research Fellow, Birmingham Cancer Research UK Clinical Trials Unit, University of Birmingham, United Kingdom [CS54]
David Burns Consultant Haematologist, University Hospitals Plymouth NHS Trust, Derriford Road, Crownhill, Plymouth, Devon, United Kingdom [CS33]
Alexandra E. Butler Professor in Pathology, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [13,CS70,CS71,CS72]
Hiu Kwan Carolyn Tang Consultant Medical Oncologist, Cambridge University NHS Foundation Trust, Cambrdige, United Kingdom [CS51]
Dimitrios Chanouzas Consultant Nephrologist, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, United Kingdom [CS31,CS32]
Amen EL Cheikh Ammar Consultant Pulmonologist and Senior Lecturer, Royal College of Surgeons in Ireland - Medical University of Bahrain Busaiteen 228, Bahrain [CS2,CS27,CS69]
Ruth Clifford Consultant Haematologist, University Hospital Limerick, Clinical Professor, GEMS, University of Limerick Hospitals Group, University Hospital Limerick, Ireland [CS16,CS52,CS55,CS57,CS58, CS62,CS67]
Pippa G. Corrie Consultant and Affiliated Associate Professor in Medical Oncology, Cambridge University Hospitals NHS Foundation Trust and University of Cambridge, United Kingdom [CS51,CS68]
Simon J. Dunmore Honorary Clinical Senior Lecturer, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen; Honorary Lecturer, Cardiovascular Sciences, School of Medicine, University of Edinburgh; NHS Scotland (Grampian) [12,13,CS70,CS71,CS72]
Kevin Dunne Professor of Paediatrics, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS43]
J. David M. Edgar Consultant Immunologist, St. James's Hospital and Trinity College, Dublin, Ireland [6,CS20,CS23,CS30,CS31,CS33,CS39]
Éanna Fennell Irish Research Council Postdoctoral Fellow, Limerick Digital Cancer Research Centre, School of Medicine, Bernal Institute and Health Research Institute, University of Limerick, Limerick, Ireland [CS11,CS57]
Fidelma Fitzpatrick Professor and Head of Department of Clinical Microbiology, RCSI and Consultant Microbiologist, Beaumont Hospital, Dublin, Ireland [CS9,CS12,CS13]
Siobhan Glavey Professor and Head of the Department of Pathology, RCSI, Dublin, and Consultant Haematologist, Department of Haematology Beaumont RCSI Cancer Centre, Dublin, Ireland [CS16,CS62]
Alexander Glover Clinical Research Fellow, Institute of Immunology and Immunotherapy, University of Birmingham Birmingham, United Kingdom [CS63]
Kate Glover Principal Clinical Scientist, Birmingham Women's and Children's NHS Foundation Trust, Mindelsohn Way, Birmingham, United Kingdom [10,CS41,CS42,CS44,CS45, CS46,CS49]
Lorraine Hartles-Spencer Principal Clinical Scientist, West Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Mindelsohn Way, Birmingham [10]
Jamal Hasan Hashem Lecturer in Surgery, and Academic Director of Artificial Intelligence, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS10,CS17,CS28,CS38]
Eddie Jones University Hospital Limerick, St. Nessan's Road, Dooradoyle, Limerick, Ireland [CS47,CS48]
Nadira D. Karunaweera Chair and Senior Professor of Parasitology, Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka [4,CS5,CS7,CS8]
Catherine King Renal Research Fellow, Institute of Immunology and Immunotherapy, University of Birmingham, Cancer Sciences Building, Edgbaston, Birmingham [CS31,CS32]
Nitya Kumar Senior Lecturer in Public Health and Epidemiology, Royal College of Surgeons in Ireland - Medical University of Bahrain, Bahrain [2]
Daniela Kurfürstová Department of Clinical and Molecular Pathology, Palacky University and University Hospital Olomouc, Czech Republic [CS66]
Ciara Leahy Irish Research Council PhD Student, Limerick Digital Cancer Research Centre, School of Medicine, Bernal Institute and Health Research Institute, University of Limerick, Limerick, Ireland [CS63]
Mary Lynch Al Tarief Consultant Cardiologist, Mohammed Bin Khalifa Bin Salman AlKhalifa Cardiac Center, Adjunct Professor of Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS35,CS36,CS37,CS40]
Laila Ayelet Mizrahi Medical Student, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS4,CS36,CS44]
Sara Mohamed Clinical Educator in Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS9,CS21,CS26,CS40,CS59]
Fatima Moh'D Muhsen Khader Atieh Medical Student, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS12,CS21,CS30,CS32,CS35,CS36, CS39,CS59]
Paul G. Murray Professor of Pathology and Head of the Department of Pathology, Royal College of Surgeons in Ireland - Medical University of Bahrain, Professor of Molecular Pathology, University of Limerick, Ireland, and Honorary Professor, University of Birmingham, United Kingdom [1,3,4,5,6,7,8,9,10,11,14,CS1, CS3,CS4,CS5,CS6,CS7,CS10,CS11,CS12,CS15, CS16,CS17,CS18,CS19,CS21,CS24,CS25,CS26, CS27,CS28,CS31,CS32,CS35,CS36,CS37,CS38, CS39,CS43,CS44,CS50,CS52,CS54,CS55,CS56, CS57,CS58,CS59,CS60,CS61,CS62,CS63,CS64, CS65,CS68,CS69]
Shantha Perera Visiting Senior Lecturer, School of Life Sciences, University of Wolverhampton, United Kingdom [6,CS3]
Niamh Peters Consultant Medical Oncologist, University of Limerick Hospitals Group, University Hospital Limerick, St. Nessan's Road, Dooradoyle, Limerick, Ireland [CS41,CS53, CS59,CS60,CS61,CS66]
Matthew Pugh Jean Shanks / Pathological Society Intermediate Clinical Fellow, Associate Clinical Professor, Honorary Consultant Histopathologist, University Hospitals Birimingham Foundation Trust [CS3,CS11,CS55,CS57, CS63,CS67,CS68]
Sara Bashar Qasrawi Medical Student, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS21]
Denis S. Quill Associate Professor in Surgery, Department of Surgery, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS50]
Sara Mohammed Ahmed Rady Medical Student, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen 228, Bahrain [CS20,CS22,CS37,CS38]
Aisling Ross Marie Sklodowska-Curie Actions Research Fellow, Bernal Institute and School of Medicine, University of Limerick, Ireland, and Walter and Eliza Hall Institute of...
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