Cannabis and Khat in Drug Discovery: The Discovery Pipeline and the Endocannabinoid System provides comprehensive coverage of two important psychoactive plants: Khat and Cannabis. Initial research has found that compounds and derivatives from Cannabis and Khat are found to have promising properties that can be used for the discovery, design and development of potential drug leads against various diseases. This book extensively discusses the drug discovery and allied sciences of these compounds in the drug discovery pipeline, including basic research and computer aided modeling in ligand-drug interactions and their interactions with the endocannabinoid system.
Categorized into sections including, chemical analyses and bioassays, medicinal chemistry, chemical biology and pharmacology, clinical applications, and policy and regulations, this book covers the methods and protocols involved and will be of interest to students, researchers, policymakers and all those involved in drug discovery research.
- Covers the medicinal chemistry, pharmacology and biological chemistry of cannabis, khat, their constituent compounds and metabolites
- Presents both the adverse and the beneficial entities to health and drug discovery
- Includes detailed methods and protocol information to allow easy replication and application
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-95928-5 (9780323959285)
Schweitzer Klassifikation
Part A: Introduction1. Introduction to Catha edulis and Cannabis2. Ethnomedicinal uses of cannabis3. Ethnomedicinal uses of Catha edulis4. Cannabis chemotypes: sativa, indica, and others5. Cannabinoids and their subclasses - Lucia Kabanga6. The Chemistry and Pharmacology of Tetrahydrocannabinol and Cannabidiol7. Cannabis infused foods: Efficacy, safety and regulation8. Water resource demands and management in the growth of cannabis industrializationPart B: Chemical analyses and bioassays1. Extraction and isolation of cannabinoids2. Chromatographic fingerprinting and spectroscopic profiling of cannabinoids3. Antiviral properties of cannabidiol (CBD)4. In vitro and in vivo assays and safety profiles of cannabinoids5. In vitro and in vivo toxicology of cannabinoids6. Immunomodulatory properties of cannabis7. Pharmacologically active ingredients from Catha edulis8. Phytochemistry of Catha edulis9. In vitro and in vivo assays and toxicity profile of Catha edulis10. Physicochemical properties of Catha edulis11. Cannabis and reproductive physiologyPart C: Medicinal Chemistry, Chemical Biology and Pharmacology1. Cannabinergics2. Medicinal Chemistry of cannabinoids and endocannabinoids3. Biosynthesis of cannabinoids and endocannabinoids4. Cannabinoid ligands and receptors5. Medicinal Chemistry of selected active compounds in Catha edulis6. Catha edulis, Cannabis and the nervous system7. Structural analysis of Catha edulis's sympathomimetric amines to amphetamine and adrenaline8. Stimulants from Catha edulis9. Catha edulis and concomitant drug bioavailability10. Interactions of Catha edulis agents with CB2 receptors11. In Silico Drug Design Studies of Bioactives in Catha edulis, Cannabis, and their derivativePart D: Catha edulis and cannabinoids in disease management; Clinical aspects Prologue to part D 1. Cannabis in pain management2. Cannabinoids in cancer management3. Cannabis in antimicrobial drug development4. Cannabis in fungal infection management5. Cannabis in Post-traumatic stress disorder management6. Cannabis use in Unani Medicinal practices7. Catha edulis in antimicrobial drug development8. Dependence syndrome in Catha edulis product uses9. Catha edulis in pain management10. Catha edulis and type 2 diabetes mellitus11. Catha edulis in the management of cancers12. Clinical uses of cannabis and Catha edulis products13. Cannabinoid therapy and concomitant administered agents14. Dependence syndrome in cannabis product uses15. Hepatocellular injury from Catha edulis16. Innovative cannabis products on the market17. Pestcides and disease causing contaminants in Khat and khat productsPart E: Policy and regulations1. Industrial and medical use approvals and regulations of Cannabis products2. Conservation of Cannabis species and their products3. Policy and Regulation of Catha edulis product uses4. Future perspectives on the use of cannabis and Catha edulis products
