Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.
- Highlights induction and validation of different available experimental models of Parkinson's Disease
- Provides a comparative prospect of different experimental models of Parkinson's Disease
- Discusses the advantages and disadvantages of each model, including associated limitations
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Verlagsort
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ISBN-13
978-0-443-16129-2 (9780443161292)
Schweitzer Klassifikation
Section I. Understanding PD and related movement disorders1. Neuroinflammation, glymphatic system, and Parkinson's disease2. Pharmacotherapy of PD and related movements disorders and their limitations3. Diagnosis and biomarkers of Parkinson's disease and related movement disorders4. OMICS and bioinformatics in Parkinson disease and related movements disorders5. Modeling Parkinson's disease with the alpha-synuclein protein6. a-Synuclein seeding assay and analysisSection II. Mammalian models of Parkinson's disease7. SHH, nurr1, pitx3, and en1 models for Parkinson's disease8. Stem cell for PD: Technical considerations9. Deep brain stimulation using animal models of Parkinson's disease10. The MitoPark mouse model of Parkinson's disease11. The beta-sitosterol beta-D-glucoside (BSSG) rat model of Parkinson's diseaseSection III. Invertebrate models of Parkinson's disease12. SCA1 zebrafish model13. Various zebrafish models of Parkinson's disease: What gives us hope14. Drosophila PD model15. Caenorhabditis elegans models of tauopathy16. LRRK2 in Caenorhabditis elegans modelSection IV. Ethics and regulations related to translational PD models17. Confounding factors for validation of PD models18. Neurobehavioral characterization of PD models19. Ethical regulations for induction and validation of PD models20. The OMICS and PD models: Hopes or hypes21. Parkinson's disease from an Ayurveda perspective: Opportunities and challenges for further research
