Population Genomics in the Developing World: Concepts, Applications, and Challenges, a new volume in the Translational and Applied Genomics series, provides a comprehensive, up-to-date summary of the field of population genomics in developing countries. This book equips students, researchers, and clinicians with the practical skills and approaches necessary to face the unique challenges and opportunities of practicing population genomics in developing countries. Following a brief foundational overview, more than a dozen authors working in developing nations share applied case studies from the field, including rationale, methods, analysis, and outcomes to reinforce understanding. Key themes across the country-specific chapters include efficient genetic data generation and effective computational and statistical tools to analyze population-level data. This book then discusses clinical interpretation of these data, from direct-to-consumer ancestry testing to translational and applied precision medicine. A final chapter considers the ethical aspects of conducting genomic research in developing countries.
- Addresses the unique opportunities to positively impact global health by practicing population genomics in developing countries
- Features applied case studies from genomic research in various developing nations, with clear instruction in research rationale, methods, tools, materials used, analysis, and outcomes
- Features international chapter authors and population genomics experts practicing in South Africa, Gabon, India, South America, Central America, and Honduras, among other locations
Sprache
Verlagsort
Dateigröße
ISBN-13
978-0-443-18547-2 (9780443185472)
Schweitzer Klassifikation
1. Population genomics - The fundamentals2. Why focus on population genomics in developing countries?3. Contribution of large consortia studies to population genomics in the developing world: Examples from Africa and South Asia4. Implementing genomics research in developing countries: Common challenges, and emerging solutions5. Next-generation sequencing technologies: Implementation in developing countries6. Computational disease-risk prediction: Tools and statistical approaches7. Genotype versus phenotype versus environment8. Implementing population pharmacogenomics: Tailoring drug therapy for diverse populations9. Direct-to-consumer (DTC) genetic testing and the population genomics industry10. Clinical translation of genomics research in Africa - Mainstreaming medical ethics, equity, genetics education, and public engagement11. The future of population genomics in developing countries