Modern Methods of Drug Design and Development

1. Recombinant protein purification for structural and kinetic studiesMatthew Lloyd, Otsile Mojanaga and K Ravi Acharya2. Steady-state kinetic analysis of reversible enzyme inhibitorsMatthew Lloyd3. Steady-State Enzyme KineticsBharath Srinivasan4. Analysis of enzyme kinetic data using ICEKATBrian C. Smith5. NMR techniques in drug discoveryTim Woodman6. Dynamic simulations and pre-steady state kinetics to guide drug discoveryKen Johnson7. Design and assay of substrate-product analogues for racemases and epimerasesStephen L. Bearne8. Sensitive high throughput methods to screen for P450 inhibition: A- MI complex forming drugsRheem Totah9. Sensitive high throughput methods to screen for P450 inhibition: B-Heme loss causing drugsRheem Totah10. Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosisSylvie Garneau-Tsodikova and Oleg Tsodikov11. Crystallographic fragment screening in academic cancer drug discoveryJane Endicott, Martin Noble and Mathew Martin12. Fast fragment- and compound-screening pipeline at the Swiss Light SourceJustyna A. Wojdyla, May E. Sharpe and Guenter Fritz13. Chemical biology, enzymology and drug discoveryKevin Dalby14. PROTACsMatthias Baud15. Proximity-Induced Pharmacology (PROTACs)Matthieu Schapira16. Chemo-enzymatic Labelling with asparaginyl endopeptidase (AEP)Louis Luk17. Development of 5-Aminolevulinic Acid Prodrugs for Photodynamic Therapy and PhotodiagnosisIan Eggleston18. Systems biology and single cell approachesUdo Opperman