Mitochondrial Diseases

Section I. Introduction to Mitochondrial Diseases 1. Mitochondrial disease in neurology - Past, present, and future Section II. Most Common Neurological Manifestations of Mitochondrial Disease2. Progressive external ophthalmoplegia3. Mitochondrial optic neuropathies4. Leigh syndrome5. Stroke-like episodes in adult mitochondrial disease6. Ataxia and spastic paraplegia in mitochondrial disease7. Peripheral neuropathy in mitochondrial disease8. Complex neurological and multisystem presentations in mitochondrial disease Section III. Diagnosing Mitochondrial Disease9. Investigation of oxidative phosphorylation activity and composition in mitochondrial disease10. Genetics of mitochondrial diseases: Current approaches for the molecular diagnosis11. Laboratory and metabolic investigations12. Neuroimaging in mitochondrial disease Section IV. Therapy and Future Challenges13. Currently available therapies in mitochondrial disease14. Reproductive options in mitochondrial disease15. Clinical trials in mitochondrial disease16. Blood biomarkers of mitochondrial disease - One for all or all for one?17. Experimental therapy for mitochondrial diseases