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There is a rich history of the physical sciences contributing to cancer research and treatments, yet there is currently no such book that covers all of the new techniques and developments in the field of the physics of cancer. This book aims to highlight precisely these biophysical techniques and their achievements for physical cancer research to ensure they receive more attention in the scientific community.
This fifth volume of the 'Physics of Cancer (Second Edition)' series contains eight chapters dealing with biophysical methods. The first chapter presents the traditional NMR techniques and introduces the relatively new MRE technique for the characterization of cancer cells and tissues. The second chapter provides an overview of magnetic tweezer techniques relevant to cell characterization. The third chapter focusses on the magnetic twisting cytometry techniques. The fourth and fifth chapters discuss the cytoskeletal remodeling dynamics from a biological viewpoint and a physical viewpoint, respectively. The optical tweezer is introduced in the sixth chapter and the optical cell stretcher is discussed in the seventh chapter. In the eighth chapter, microfluidics-based high-throughput cell stretching is discussed and the latest developments are presented.
Current and groundbreaking references are included throughout, meaning that each chapter is perfectly suited to serve as a reference for future scientific works and to provide scientific impetus for new research approaches.
Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumormicroenvironment mechanics. She has published over 150 referred journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.
Preface
About the author
Part I Magnetics-based techniques from a physics of cancer perspective
1 Examination of cancer cells and their ambient matrix using NMR and MRE
2 Magnetic tweezer principles, results, and applications in cancer
3 Magnetic twisting cytometry of cancer cells
Part II Laser-based techniques from a cancer-specific perspective
4 Cytoskeletal remodeling dynamics of single normal and cancerous cells from a biological viewpoint
5 Cytoskeletal remodeling dynamics of single normal and cancerous cells from a physical viewpoint
6 Optical tweezers
7 Optical cell stretchers and their findings for cancer-specific issues
8 High-throughput microfluidics-based cell stretching
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