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There is a rich history of the physical sciences contributing to cancer research and treatments, yet there is currently no such book that covers all of the new techniques and developments in the field of the physics of cancer. The purpose of this book is to make these very relevant topics visible to the research field to ensure they receive more attention in the scientific community.
This fourth volume of the 'Physics of Cancer (Second Edition)' series contains four chapters dealing with mechanobiology using biophysical methods. The first chapter deals with mechanosensing and mechanotransduction on vastly different length scales. The second chapter discusses biophysical techniques for mechanical phenotype characterization of cells and nuclei. The third provides an overview of the mechanical phenotype of the plasma membrane. The fourth chapter contains the latest insights into the mechanical assessment of cell spheroids, organoids and tumoroids.
The basic approach of this text is to present the latest promising findings to the scientific community, addressing scientists at all career stages. Current and groundbreaking references are included throughout, meaning that each chapter is perfectly suited to serve as a reference for future scientific works and to provide scientific impetus for new research approaches.
Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumormicroenvironment mechanics. She has published over 150 referred journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.
Preface
Author biography
1 Mechanosensing and the mechanotransduction of cells
2 Overview and discussion of biophysical techniques for the mechanical characterization of cell nuclei and cells
3 Overview and discussion of biophysical techniques for the mechanical characterization of plasma membranes
4 A survey of biophysical techniques used for the mechanical characterization of cell spheroids, organoids, and tumoroids
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