Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Neurodegenerative Disease Research and Commonalities with Metabolic Diseases

1. Status and future directions of clinical trials in Alzheimer's diseaseGermán Plascencia-Villa and George Perry2. Tracking the potential involvement of metabolic disease in Alzheimer's disease-Biomarkers and beyondJose A. Luchsinger and Henrik Zetterberg3. Brain glucose and ketone utilization in brain aging and neurodegenerative diseasesDimitrios Kapogiannis and Konstantinos I. Avgerinos4. Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease-Learnings from brain imaging biomarkersKerstin Heurling, Edvin Johansson and Antoine Leuzy5. APOE and metabolic dysfunction in Alzheimer's diseaseLance A. Johnson6. Status and future directions of clinical trials in Parkinson's diseaseGrazyna Söderbom7. Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switchingMark P. Mattson8. The mitochondrial hypothesis: Dysfunction, bioenergetic defects, and the metabolic link to Alzheimer's diseaseRussell H. Swerdlow9. MAM and C99, key players in the pathogenesis of Alzheimer's diseaseMarta Pera, Jorge Montesinos, Delfina Larrea, Rishi R. Agrawal, Kevin R. Velasco, Irina G. Stavrovskaya, Taekyung D. Yun and Estela Area-Gomez10. Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic riskRia Thomas, Penelope J. Hallett and Ole Isacson11. Endosomal-lysosomal dysfunction in metabolic disorders and Alzheimer's diseaseMichael F. Almeida, Ben A. Bahr and Stephen T. Kinsey12. Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseasesPaul Edison13. The NLRP3 inflammasome as a bridge between neuro-inflammation in metabolic and neurodegenerative diseasesGrazyna Söderbom and Bai-Yun Zeng14. Impact of circadian and diurnal rhythms on cellular metabolic function and neurodegenerative diseasesS. Kendall Smith and Erik S. Musiek15. The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseasesMolly Braun and Jeffrey J. Iliff