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The latest edition of the key haematology text
Haematology, the study and treatment of blood and bone marrow disorders, is a rich and complex discipline that consistently produces cutting-edge medical research. Since 1972, Hoffbrand's Postgraduate Haematology has acted as the foundational overview and reference text for this subject, introducing generations of trainees and medical residents to the pathogenesis, clinical and laboratory features, and management of blood disorders.
The eighth edition of Hoffbrand's Postgraduate Haematology, now with a new editorial team including leading clinicians and researchers, promises to continue this tradition of excellence with a fully updated text. Lavishly illustrated, comprehensive, and thoughtfully referenced, it is an indispensable resource.
Readers of the eighth edition of Hoffbrand's Postgraduate Haematology will also find:
Hoffbrand's Postgraduate Haematology is ideal for all postgraduate trainees or residents in haematology, as well as for clinicians and practitioners looking for a reference work on the subject and a guide to the latest research.
Adam J Mead PhD, FRCP, FRCPath, FMedSci Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Michael A Laffan DM, MRCP, FRCPath Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK
Graham P Collins DPhil, FRCP, FRCPath Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK
Deborah Hay DPhil, MRCP, FRCPath Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Consulting Editor
A Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci Emeritus Professor of Haematology, University College London, London, UK
Honorary Consultant Haematologist, Royal Free Hospital, London, UK
About the Editors viii
Contributor's List x
Preface to the eighth edition by Adam J Mead xiv
Preface to the eighth edition by A Victor Hoffbrand xv
Preface to the first edition xvi
About the companion website xvii
Part I General principles of haematology 1
1 Human stem cells and haemopoiesis 3Petter S Woll and Adam J Mead
2 Phagocytes 15Fernando O Martinez, Giuseppe Teti and Siamon Gordon
3 Erythropoiesis in the human 43Douglas R Higgs, Christian Babbs and Mira Kassouf
4 Lymphocyte development and function 56Sean Hua Lim
5 The spleen 71Catherine Hildyard and Daniel Royston
6 Cancer immunotherapy 82Charlotte O'Brien-Gore, Sophie Papa and Shahram Kordasti
7 Clinical applications of gene editing and therapy 96Mohsin Badat and James Davies
8 Application of next-generation sequencing in haematology 106Angela Hamblin and Adele Timbs
9 The molecular basis of haematological malignancies 121Meng Wang, Niccolo Bolli and George S Vassiliou
10 Laboratory diagnosis of haematological neoplasms 142Barbara J Bain and Torsten Haferlach
Part II Red blood cell disorders and blood transfusion 163
11 Iron metabolism, iron deficiency and disorders of haem synthesis 165Clara Camaschella and Chaim Hershko
12 Iron overload 188Clara Camaschella and Maria Domenica Cappellini
13 Megaloblastic anaemia 201A Victor Hoffbrand
14 Haemoglobin and the inherited disorders of globin synthesis 222Swee Lay Thein and David Rees
15 Sickle cell disease 249Neha Bhasin and Elliott P Vichinsky
16 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 269Paola Bianchi and Narla Mohandas
17 Acquired haemolytic anaemias 292Rachel Kesse-Adu and Anietie Ekong
18 Red cell immunohaematology 309Nicole Thornton, Tom Bullock and Shubha Allard Copyrighted Material
19 Clinical blood transfusion 328Andrew Charlton, Shruthi Narayan and Shubha Allard
Part III Lymphoid disorders 361
20 The classification of lymphomas 363Elias Campo, Gerard Frigola and Stefano A Pileri
21 Adult acute lymphoblastic leukaemia 395Clare J Rowntree and Adele K Fielding
22 Childhood acute lymphoblastic leukaemia 409Sujith Samarasinghe, Anthony Moorman and Ajay Vora
23 Chronic lymphocytic leukaemia and other chronic B-cell lymphoproliferative disorders 428Emili Montserrat
24 T-cell lymphoma and lymphoproliferative disorders 452Alessandro Broccoli and Pier Luigi Zinzani
25 Hodgkin lymphoma 468Beth Phillips and Graham P Collins
26 Indolent non-Hodgkin lymphomas 482Kim Linton and William Townsend
27 Aggressive B-cell non-Hodgkin lymphoma 501Matthew R Wilson, Jessica Okosun and Kate Cwynarski
28 Multiple myeloma 524Karthik Ramasamy and Sagar Lonial
29 Amyloidosis 547Ashutosh D Wechalekar
Part IV Stem cell and myeloid disorders 561
30 Inherited aplastic anaemia/bone marrow failure syndromes 563Inderjeet S Dokal
31 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 583Austin G Kulasekararaj, Neal S Young and Judith CW Marsh
32 Acute myeloid leukaemia 605Tumas Beinortas, Paolo Gallipoli and Brian J P Huntly
33 Chronic myeloid leukaemia 630David T O Yeung and Timothy P Hughes
34 The myelodysplastic syndromes 652Johanna Ungerstedt, Magnus Tobiasson and Eva Hellström Lindberg
35 Myeloproliferative neoplasms 673Claire N Harrison, Anna L Godfrey, Mary Frances McMullin and Deepti H Radia
36 Macrophages, dendritic cells and histiocytic disorders 704Matthew Collin, Venetia Bigley and Chris Bacon
37 Stem cell transplantation 719Charles Craddock and Ronjon Chakraverty
38 Clonal haematopoiesis 745Margarete A Fabre and George S Vassiliou
Part V Haemostasis and thrombosis 757
39 Normal haemostasis 759Keith Gomez and John H McVey
40 The vascular function of platelets 782Stephen P Watson, Neil V Morgan, Paul Harrison and Gillian Lowe
41 Haemophilia and von Willebrand disease 798Michael A Laffan
42 Rare inherited coagulation disorders 819Flora Peyvandi and Marzia Menegatti
43 Acquired coagulation disorders 829Peter W Collins and Jecko Thachil
44 Congenital platelet disorders 848Maurizio Margaglione and Paul RJ Ames
45 Primary immune thrombocytopenia 861Nichola Cooper and Drew Provan
46 Thrombotic thrombocytopenic purpura (congenital and acquired) and haemolytic-uraemic syndrome 872Pier Mannuccio Mannucci, Massimo Cugno and Flora Peyvandi
47 Antithrombotic agents 886Jeffrey I Weitz
48 Pathogenesis of venous thromboembolism 902Henry G Watson
49 Prevention and management of venous thromboembolism 921Nicola Curry and Susan Shapiro
50 Pathogenesis and management of arterial thrombosis 932Willem L Bor, Dean RPP Chan Pin Yin, Jurriën M ten Berg, Constance Baaten and Hugo ten Cate
Part VI Consultative haematology, supportive care and miscellaneous disorders 947
51 Haematological aspects of conditions that occur primarily in tropical countries 949Imelda Bates and Ivy Ekem
52 Lysosomal storage disorders 966Derralynn A Hughes
53 Obstetric haematology 974Gillian Swallow and Sue Pavord
54 Neonatal haematology 989Irene Roberts and Subarna Chakravorty
55 Supportive care in the management of leukaemia 1005Renuka Palanicawandar and Jirí Pavlu°
56 General consultative haematology 1024John Willan
57 Consultative haemostasis and thrombosis 1036Michael A Laffan and Peter MacCallum
Index 1055
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