Handbook of Animal Models in Neurological Disorders will better readers' understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.
- Summarizes animal models for a variety of neurological conditions
- Contains chapter abstracts, key facts, a dictionary and a summary
- Covers both neurodegenerative diseases and other neurological conditions
- Compares and contrasts different models and experimental systems
- Includes sections on Alzheimer's, Parkinson's, brain injury, migraine, multiple sclerosis, and more
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 125 illustrations (125 in full color)
Dateigröße
ISBN-13
978-0-323-89886-7 (9780323898867)
Schweitzer Klassifikation
Section 1: Alzheimer's Disease and Dementias1. Caenorhabditis elegans model of Alzheimer's disease: applications to drug screening2. APPswe/ PS1dE9 mouse model of Alzheimer's disease: [18F]-florbetaben pet/ct imaging and beyond3. Rat model of Alzheimer: applications to brain a-beta plaque accumulationSection 2: Amyotrophic Lateral Sclerosis4. Murine modelling of familial amyotrophic lateral sclerosis, SOD1G86R: applications to ambroxol HCl5. Rat Model of amyotrophic lateral sclerosis: SOD1G93A applications to mitochondria6. Zebrafish model of amyotrophic lateral sclerosis: applications to oxidative stress studies in spinal motor neuronsSection 3: Brain Injury7. Murine models of traumatic brain injury and knock outs: investigations on hypocretin8. Rat model of cortical impact traumatic brain injury: applications to studying neural stem cell grafts9. Porcine modelling of traumatic brain injury: investigating agents such as valproic acid and beyondSection 4: Cerebral Palsy10. Animal models of cerebral palsy: a new narrative11. Rat model of cerebral palsy: applications to studying motor phenotype12. Rabbit cerebral palsy modelling: applications to studying spinal hyper-excitabilitySection 5: Epilepsy13. Murine modelling of epilepsy: applications to microRNA and hippocampus14. Kainic acid-induced rat model of status epilepticus: A gamma-aminobutyric acid levels15. Rats modelling of temporal lobe epilepsy: linking in cognitionSection 6: Headaches and Migraines16. A new narrative of genetic mouse models of migraine: features and applications17. Rat model of headache with nitroglycerin: impact of auricular electrical stimulation18. Nitroglycerin-induced migraine in mice: Nociceptin Opioid (NOP) receptors and beyondSection 7: Meningitis Rabbit tuberculous meningitis models: applications to neurosciences19. Experimental pneumococcal meningitis: hippocampal DNA methylation20. Pneumococcal meningitis modelling in miceSection 8: Multiple Sclerosis Biological models in multiple sclerosis: a new overview and narrative21. The mouse model of multiple sclerosis : use of Artemisia dracunculus L.22. Comparing models of multiple sclerosis: applications to biomarkersSection 9: Neuroinflammation Modelling neuroinflammation: CXCR2 signalling and myelin repair23. Lipopolysaccharide- model of neuroinflammation: astrogliosis, microglial activation and beyond24. Rat model of neuroinflammation: positron emission tomography (PET) tracer for imaging of P2X7 receptorsSection 10: Neurotoxins Animal models in the neurotoxicology of the neurotoxin 2,4-D25. Toluene as a model neurotoxin in mouse models 1-11-201926. Rat model of alcohol-related brain damage: application to thiamine deficiency and cytokinesSection 11: Parkinson's Disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine( MPTP)-induced mouse model of Parkinson's disease: impact of Valeriana officinalis27. alpha-synuclein BAC transgenic mice model of Parkinson's disease: the sublaterodorsal tegmental nucleus and beyond28. Rat model of parkinsonism: the nigro-vagal pathwaySection 12: Peripheral Neuropathy Non-mammalian animal models of peripheral neuropathy29. Mouse models of peripheral neuropathy: neurogenic molecule NSI-18930. Rat model of cisplatin-induced peripheral neuropathy: features and applicationsSection 13: Prenatal Related Injury Porcine model of intrauterine growth restriction: Applications to the study of the hippocampus31. Ethanol as a neurotoxin in model primates for in vitro exposure: brain development and beyond32. Prenatal malnutrition: linking in oxidative stressSection 14: Stroke Mouse model of ischemic stroke: PET tracers33. Canine model of stroke: optimizing complex multimodal treatment34. Porcine Ischemic Stroke and applications to neural stem cells
