Regulated Cell Death in Neurodegenerative Disorders is a comprehensive exploration of the mechanisms and implications of RCD within the realm of neurodegenerative diseases. The book delves into various forms of RCD such as apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death, shedding light on their specific roles in disorders like Alzheimer's, Parkinson's, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington's. Written by leading experts, each chapter offers unique insights into cellular demise, providing valuable information on treatment options and therapeutic targets. The book features 14 chapters that cover molecular, cellular, and pharmacological mechanisms from an applied science perspective.Topics include the importance of chaperones, kinases, growth factors, inflammaging, mitochondrial dynamics, and oxidative stress. It presents targeted strategies to prevent cell death, reflecting ongoing pursuits in understanding and innovating treatments for neurodegenerative diseases. By offering therapeutic strategies to modulate RCD, this book not only shares knowledge but also provides hope for future advancements in combating these debilitating conditions.
- Provides a comprehensive overview of different types of RCD
- Dissects the crosstalk between different types of RCD
- Explores the relevance of RCD mechanisms to neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington's disease
- Examines several forms of regulated cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death
- Discusses the effect of Inflammaging and oxidative stress on different types of RCD
- Delves into the effect of chaperones, kinases, and growth factors on different RCD machinery
- Discusses the potential of targeted therapies aimed at interdicting cell death machineries
- Explores disease-modifying agents targeting RCD in neurodegenerative disorders
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ISBN-13
978-0-443-32853-4 (9780443328534)
Schweitzer Klassifikation
Chapter 1. Regulated Cell Death: Discovery, Features, and Implications for Neurodegenerative DiseasesChapter 2. Crosstalk Between Different Regulated Cell Death Mechanisms in Neurodegenerative DiseasesChapter 3. Apoptosis in Neurodegenerative DisordersChapter 4. Necroptosis in Neurodegenerative DisordersChapter 5. Ferroptosis in Neurodegenerative DisordersChapter 6. Pyroptosis in Neurodegenerative DisordersChapter 7. Autophagy-Mediated Cell Death: Mechanisms and Implications in Neurodegenerative DisordersChapter 8. Potential targets for regulating cell death in neurodegenerative diseasesChapter 9. Neuroprotective Role of Molecular Chaperones: Regulating Cell Survival and DeathChapter 10. Navigating the Kinases Landscape: Impact on Regulated Cell Death mechanisms in Neurodegenerative disordersChapter 11: Growth Factors and regulated cell death in neurodegenerative disordersChapter 12. Regulated Cell Death and Inflammaging in Neurodegenerative DisordersChapter 13. Role of Oxidative Stress and Mitochondrial Dysfunction in Neurodegenerative DisordersChapter 14. Therapeutic Approaches Targeting Regulated Cell Death in Neurodegenerative Diseases: Current Understanding and Recent Advances in Combating Neuronal Loss
