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Building on the foundation of the first edition, this thoroughly updated volume reflects the rapid advancements and expanding clinical relevance of navigated transcranial magnetic stimulation (nTMS) in neurosurgery. Once primarily a tool for preoperative mapping of cortical motor and language functions, nTMS is now increasingly recognized as a versatile instrument for individualized neurosurgical planning, risk stratification, and targeted neuromodulation.
This second edition presents these principles of perioperative neurophysiology with new insights into the integration of nTMS with cutting-edge technologies such as advanced tractography and connectomic analyses offering a more nuanced view of brain networks and their role in both mapping and therapeutic contexts. Emerging applications-such as closed-loop stimulation and post-spinal cord injury rehabilitation-are covered in depth, reflecting the field's shift toward personalized neuromodulatory interventions.
As in the first edition, the book serves both as a practical guide and a reference: neurosurgeons and neuroscientists new to nTMS will find essential protocols and implementation strategies, while experienced users will benefit from expert analysis of the latest techniques and clinical applications. Each chapter is authored by leading figures in the field, selected for their pioneering contributions and international expertise.
With a spirit of collaboration and innovation at its core, this book captures the momentum and promise of nTMS in modern neurosurgery-moving from isolated functional regions to a network-based approach that is transforming patient care.
Prof. Thomas Picht (Charité - Universitätsmedizin Berlin) and Prof. Sandro Krieg (Heidelberg University Hospital) have been at the forefront of advancing navigated transcranial magnetic stimulation (nTMS) in neurosurgery for over a decade. As internationally recognized experts in eloquent brain tumor surgery, they have relentlessly driven innovation in non-invasive brain mapping, helping to refine surgical strategies and improve patient outcomes. Their collaboration is marked by a strong commitment to international exchange, reflected in numerous joint publications with global partners and their long-standing role as co-hosts of the annual International Symposium on nTMS in Neurosurgery. Together, they have shaped the clinical translation of nTMS from cutting-edge research to a widely adopted tool in neurosurgical planning. Their combined efforts continue to push the boundaries of technology-driven, patient-centered neurosurgical care.
Chapter 1. Basic Principles of Navigated Tms.- Chapter 2. TMS, MEG and fMRI: Comparing and Contrasting three Functional Mapping Techniques.- Chapter 3. Basic and Advanced Intraoperative Neurophysiological Monitoring and Mapping in Supratentorial Brain Tumor Surgery.- Chapter 4. Integration of Functional Data in The Clinical Workflow.- Chapter 5. Safety Issues for The Use Of TMS.- Chapter 6. nTMS Motor Mapping: Basic Principles and Clinical Use.- Chapter 7. nTMS-based DTI Fiber Tracking of Motor Pathways.- Chapter 8. nTMS Motor Mapping for Risk Stratification and Clinical Decision Making Support.- Chapter 9. nTMS Language Mapping: Basic Principles and Clinical Use.- Chapter 10. Combining nTMS And Tractography for Language Mapping: an Integrated Paradigm for Neurosurgical Planning.- Chapter 11. Risk Stratification by nTMS Language Mapping.- Chapter 12. Mapping of Further Brain Functions.- Chapter 13. nTMS In Pediatrics: Special Issues and Solutions.- Chapter 14. nTMS in Epilepsy: Functional Mapping and Therapeutic Applications.- Chapter 15. Assessment of Chronic Cervical Myelopathy.- Chapter 16. Navigated rTMS for the Treatment Of Pain.- Chapter 17. High-PAS: Paired Associative Stimulation with High-Frequency Peripheral and High-Intensity Central Component in Spinal Cord Injury Rehabilitation.- Chapter 18. Treatment of Paresis.- Chapter 19. Closed-Loop TMS.- Chapter 20. nTMS Depression Therapy.- Chapter 21. Harnessing Advanced Tractography in Neurosurgical Practice.- Chapter 22. Analysis and Creation of Structural Connectomes in Brain Tumour Patients: Methodological Challenges and Potential Solutions.- Chapter 23. Brain Plasticity and Neurosurgery.- Chapter 24. Outlook on The Potential of nTMS in Neurosurgery.
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