Essential Tremor: Current Concepts and Controversies

1. What's in a name? nomenclature of essential tremor- syndrome or family of diseases?Louis & KuoIs essential tremor a family of diseases or a syndrome? A family of diseasesRiboldi & FruchtIs essential tremor a family of diseases or a syndrome? A syndromePandey 2. Essential tremor- Is this an electrical or a degenerative disorder? Or is it both?Louis & KuoIs essential tremor a degenerative disorder or an electric disorder? A degenerative disorderFaustIs essential tremor a degenerative disorder or an electric disorder? An electric disorderCho 3. How important is the inferior olive in essential tremor? An evolving storyKuo & LouisIs inferior olive central to the pathophysiology of essential tremor? YesLang & HandforthIs inferior olive central to the pathophysiology of essential tremor? NoManto 4. Essential tremor as a harbinger- what is the cognitive fallout of having essential tremor?Louis & KuoDoes essential tremor increase the risk of dementia? YesCosentino & ShihDoes essential tremor increase the risk of dementia? NoRajput 5. Is essential tremor a disorder primarily due to GABA dysfunction?Kuo & LouisIs essential tremor a disorder of primary GABA dysfunction? YesGironellIs essential tremor a disorder of primary GABA dysfunction? NoBellows &Jimenez-Shahed 6. The future of pharmacotherapies for essential tremor: enhancing GABA neurotransmission or reducing neuronal hyper-excitability?Kuo & LouisWhat is the next generation of medication for essential tremor? Enhancing GABAergic inhibitionOndoWhat is the next generation of medication for essential tremor? Reduction of hyper-excitabilityShukla