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This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging. In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN.
SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering.
SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity.
This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists.
Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, USA. Dr. Claudia Sommer is a professor of Neurology at the Department of Neurology, Würzburg University Hospital, Germany.
"An abundance of references at the end of each chapter makes it easy for physicians to investigate further when a specific clinical question arises. As the first of its kind, this book should be considered a core reference for experts who regularly encounter SFN and must be strongly considered by any physician or trainee interested in improving their pain management skills." (Brett A. Toimil and Amanda M. Kleiman, Anesthesia & Analgesia, Vol. 130 (3), March, 2020)
Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine and the director of Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, US. Dr. Claudia Sommer is a professor and the assistant medical director of Department of Neurology, Würzburg University Hospital, Germany.
Overview of small fiber neuropathy and clinical aspects of small fiber neuropathy.- Pathology of small fiber neuropathy: skin biopsy for nociceptive nerve.- Neurophysiology: evoked potential.- Psychophysics.- Autonomic examinations and nerve pathology.- Diabetic neuropathy, metabolic syndrome.- Genetic small fiber neuropathy.- Amyloid neuropathy.- Small fiber involvment in conventional large fiber neuropathy.- Vasculitis and autoimmune disorders, infectious neuropathy.- Pain syndromes.- Visceral pain and hypersensitivity disorders.- Small fiber pathology in neurodegenerative disorders.- Neuropathic pain in small fiber neuropathy.- Therapy for small fiber neuropathy.
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