Autophagy Dysfunction in Alzheimer's Disease and Dementia

Section I. Degradation mechanisms of cells1. Degradation mechanisms of cells Section II. Lysosomes2. Lysosomes-neuronal degeneration in lysosomal storage disorders Section III. The autophagic pathways3. The autophagy pathway and its key regulators Section IV. Amyloid beta protein and autophagy 4. Basics of amyloid beta protein in Alzheimer's disease5. Molecular linkages among Aß, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer's disease6. Endocytosis in ß-amyloid biology and Alzheimer's disease Section V. Autophagy and tau protein 7. Autophagy and tau protein 8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes 9. Tau propagation and autophagy Section VI. Autophagy and pathology in Alzheimer's disease 10. Granulovacuolar degeneration in neurodegeneration11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease Section VII. Autophagy and other disorders causing dementia12. Autophagy in Lewy body diseases and multiple system atrophy 13. Autophagy and Huntington's disease Section VIII. Drug discovery in Alzheimer's disease by modulating autophagy14. Drug discovery in Alzheimer's disease by regulating autophagy15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses16. Development of autophagy enhancers for Parkinson's disease therapy