Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies.
The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.
- Comprehensive coverage of the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade
- Introduces the most recent imaging technologies to characterize factors, including aortic geometry, mechanical properties of aortic tissues, and cellular activity in the vessel wall
- Synthesizes advances in vascular biomechanics, medical imaging, and computational modeling of finite element fluid and solid models
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-95485-3 (9780323954853)
Schweitzer Klassifikation
PART 1 Anatomy, biology, physiopathology1. Physiopathology2. Genetics of aortic disease3. Mechanobiology of aortic cells and extracellular matrix4. Clinical treatment optionsPART 2 Imaging and tissue/rheology characterization5. Novel experimental methods to characterize the mechanical properties of the aorta6. Imaging aortic flows in 4D using MRI7. Ultrasound imaging for aortic biomechanics8. Functional imaging, focus on [18F]FDG positron emission tomography9. Image processing: Deep learning for aorta model reconstructionPART 3 Tissue modeling and rupture10. On simulation of the biophysical behavior of the aortic heart valve interstitial cell11. Abdominal Aortic Aneurysm and thrombus modeling12. Computational modeling of aneurysm growth in mechanobiology13. Analysis of aortic rupture: A computational biomechanics perspective14. Multiscale modeling of aortic mechanics: Tissue, network, and proteinPART 4 Flow modeling and algorithm15. Multiphysics flow modeling in the aorta16. Novel Approaches for the numerical solution of fluid-structure interaction in the Aorta17. Turbulence modeling of blood flow18. Inverse problems in aortic flow modeling19. Modeling of flow induced mechanosignaling20. Reduced order modeling of cardiovascular hemodynamicsPART 5 Applications21. Transcatheter aortic valve implantation (TAVI)22. Abdominal Aortic Aneurysm rupture prediction23. (T)EVAR simulation24. Fluid Structure Interaction (FSI) in aortic dissections25. Pharmacological treatments, mouse models, and the aorta