Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.
It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.
- Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease
- Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins
- Covers the topic from fundamental knowledge to the latest developments in clinical application
- Includes a section dedicated to therapeutic applications
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-99522-1 (9780323995221)
Schweitzer Klassifikation
Section I: Introduction 1. Current perspectives on transcription and translational regulators in Health and diseases 2. Role of alternative splicing in health and diseases
Section II: Transcriptional and translational regulators in cancer 3. Transcriptional regulation in cancer progression 4. Role of transcriptional and post-transcriptional regulation of sphingolipid genes in molecular heterogeneity of breast cancer 5. Who dictates and when: Genetic and epigenetic dictatorships in breast cancer response and resistance to therapy 6. CRISPR/Cas9 mediated regulation in cancer 7. Biomarkers for Diagnosis, Prognosis, Treatment of Gastro-Intestinal cancer 8. Regulation of post-transcriptional events by RNA-binding proteins 9. The language of post-translational modifications in cancers and other diseases 10. Ubiquitin proteasome system-mediated regulation of protein function and stability 11. Post-transcriptional regulations in epithelial-tomesenchymal transition and endothelial-to-mesenchymal transitions
Section III: Transcriptional and translation regulators of other diseases 12. Noncoding RNAs in Diabetes 13. MicroRNAs as epigenetic regulators for gut microbiome 14. Cross talk between miRNAs and epigenetics during braindevelopment and neurological diseases15. The role of non-coding RNAs in rheumatoid arthritis 16. Role of miRNA in autoimmune and inflammatory skin diseases 17. Current Advances in Cancer Prevention and Treatment by Natural Products 18. Therapeutic inhibition of pro-inflammatory cytokins by phytochemicals in osteoarthritis 19. Redox Signaling and Cardiovascular Disease: New Paradigms and discoveries
Section IV: Therapeutics 20. Modulation of epigenetic enzymes by natural agents 21. Inhibitors targeting epigenetic modifications in cancer 22. Drug rechanneling a new paradigm for cancer treatment
