Advances in Applied Microbiology

Name: Advances in Applied Microbiology
Brand: Academic Press
Price: 102.0 EUR
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Geoffrey M. Gadd Sima Sariaslani(Herausgeber*in)

Academic Press

Erschienen am 18. August 2023

232 Seiten

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978-0-443-19275-3 (ISBN)

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Front Cover
Advances in APPLIED MICROBIOLOGY
Copyright
Contents
Contributors
Chapter One: Promoters and introns as key drivers for enhanced gene expression in Saccharomyces cerevisiaeIME in S. cerevisiae
1 Introduction
2 Promoter structure and function in S. cerevisiae
2.1 Promoters for recombinant expression in S. cerevisiae
2.2 Promoter engineering
3 Introns and intron-mediated enhancement of transcription
3.1 Intron architecture and splicing mechanisms
3.2 Proposed mechanisms for IME in S. cerevisiae
3.3 IME for recombinant gene expression in S. cerevisiae
4 Conclusions
References
Chapter Two: Significance of the plasma membrane H+-ATPase and V-ATPase for growth and pathogenicity in pathogenic fungiSignificance of the plasma membrane H+-ATPase and V-ATPase
1 pH homeostasis and its role in pathogenic fungi
1.1 The role of pH homeostasis in cell growth of pathogenic fungi
1.2 pH homeostasis and virulence of pathogenic fungi
1.3 A potential strategy for antifungal targets discovery based on pH homeostasis
1.4 Regulation of pH in pathogenic fungi
2 The plasma membrane H+-ATPase in pathogenic fungi
2.1 Structure of plasma membrane H+-ATPase in pathogenic fungi
2.2 Regulation of plasma membrane H+-ATPase activity in pathogenic fungi
2.3 Significance of PMA and its action mode in cell growth of pathogenic fungi
2.4 Significance of PMA on virulence of pathogenic fungi
3 V-ATPase in pathogenic fungi
3.1 Structure of V-ATPase in pathogenic fungi
3.2 Regulation of V-ATPase in pathogenic fungi
3.3 Significance of V-ATPase in cell growth of pathogenic fungi
3.3.1 Significance of V-ATPase in cell growth of pathogenic fungi and its action mode
3.3.2 Action mode of V-ATPase in regulating cell growth of pathogenic fungi
3.3.3 V-ATPase involving in fungicide resistance of pathogenic fungi
3.4 Significance of V-ATPase on virulence of pathogenic fungi
4 Coordination of V-ATPase and Pma1 in regulating pH homeostasis in pathogenic fungi
5 Conclusions and perspectives
Acknowledgments
References
Chapter Three: Halotolerance mechanisms in salt-tolerant cyanobacteriaHalotolerance mechanisms in salt-tolerant cyanobacteria
1 Introduction
2 Environmental salinity and cyanobacteria
3 Major protective mechanisms against high salinity in cyanobacteria
3.1 Signal transduction
3.1.1 Cell-signaling circuit operated by TCS
3.1.2 Genome-based analysis of cyanobacterial TCS
3.1.3 Identification of TCS genes that are uniquely upregulated during salt stress in Halothece
3.1.4 Identification of TCS genes in other cyanobacteria
3.2 Sodium extrusion system
3.2.1 Identification and characterization of secondary transporters vital for sodium extrusion in halotolerant cyanobacteria
3.2.2 Sodium extrusion systems in other cyanobacteria
3.3 Molecular aspects of osmoprotectant accumulation
3.3.1 Overview: coping with high salinity by an "organic-osmolyte mechanism"
3.3.2 Major groups of osmoprotectants found in cyanobacteria
3.3.3 Features, protective effect, biosynthesis, and regulation of osmoprotectants
3.3.3.1 Glycine betaine (GB)
3.3.3.2 Homoserine betaine
3.3.3.3 Glutamate betaine
3.3.3.4 Mycosporine-2-glycine (M2G)
3.3.3.5 Glucosylglycerol (GG)
3.3.3.6 Glucosylglycerate (GGA)
3.3.3.7 Sucrose
3.3.3.8 Trehalose
4 Other molecular mechanisms associated with salt stress tolerance
4.1 Primary metabolic pathways
4.1.1 Photosynthesis
4.1.1.1 Light reaction
4.1.1.2 Dark reaction
4.1.2 Glycolysis
4.1.3 Fructose-bisphosphate aldolase
4.2 Nitrogen fixation
4.3 Amino acid metabolism
4.4 Phosphorus metabolism
4.5 Protein homeostasis
4.6 Glutathione S-transferase
4.7 Alkanes and lipids
4.8 Circadian clock
5 Global transcriptional landscape under high salinity in halotolerant cyanobacteria
6 Conclusion
References
Chapter Four: From methane to value-added bioproducts: microbial metabolism, enzymes, and metabolic engineeringFrom methane to value-added bioproducts
1 Introduction
2 Methane metabolism in microorganisms
2.1 Methanotrophs
2.2 Metabolic pathways for methane utilization
3 Key enzymes involved in methane metabolism in methanotrophs
3.1 Methane monooxygenase
3.2 Methyl-coenzyme M reductases (MCRs)
3.3 Methanol dehydrogenase (MDH)
4 Bioconversion of methane to value-added bioproducts
4.1 Challenges in methane biooxidation and bioconversion
4.2 Metabolic engineering for biosynthesis based on RuMP pathway
4.3 Biosynthesis from methane based on MEP pathway
4.4 Metabolic engineering for biosynthesis based on serine cycle
4.5 Metabolic engineering for synthesis based on EMC pathway
5 Conclusions
Acknowledgments
References
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