ForewordMelvin Andersen
PrefaceJeffrey W. Fisher, Zhoumeng Lin and Jeffery M. Gearhart
1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topicsZhoumeng Lin and Jeffrey W. Fisher
2. Introduction to classical pharmacokineticsShruti V. Kabadi and Zhoumeng Lin
3. Fundamentals of physiologically based pharmacokinetic modelingJeff Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand and Zhoumeng Lin
4. Physiologically based pharmacokinetic modeling softwareC.E. Hack, A.Y. Efremenko, S.N. Pendse, C.A. Ellison, A. Najjar, N. Hewitt, A. Schepky and H.J. Clewell III
5. Chemical absorption and writing code for portals of entryJeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr and Darshan Mehta
6. Physiologically based pharmacokinetic model: distribution processesChristopher Ruark
7. Metabolism and physiologically based pharmacokinetic modelsJeffrey W. Fisher, Jerry L. Campbell Jr. and Zhoumeng Lin
8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breathSami Haddad and Andy Nong
9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysisTammie R. Covington and Jeffery M. Gearhart
10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessmentZhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou and Miao Li
11. Examples of physiologically based pharmacokinetic modeling applied to risk assessmentLisa M. Sweeney and Jeffery M. Gearhart
12. Physiologically based pharmacokinetic models to support modernized chemical safety assessmentMiyoung Yoon
