Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.
- Provides detailed overviews of the biology, including phylogenesis, biogenesis and distribution of expression, of cholecystokinin peptides and receptors
- Explores the physiology of CCK, its metabolic functions, and role in a range of medical conditions, including obesity, type 2 diabetes, tumors, nociception, and cerebral disease
- Considers the latest developments in CCK-based therapeutic approaches and future directions for CCK research
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978-0-443-23721-8 (9780443237218)
Schweitzer Klassifikation
Part I - History1. Milestones in the history of cholecystokininJens F. Rehfeld, Christine Feinle-Bisset Part II - Biology of cholecystokinin2. Evolutionarily conserved roles of cholecystokinin signalingDick Nässel, Shunfan Wu 3. The biogenesis and cell-specific expression of cholecystokinin peptidesJens F. Rehfeld, Christine Feinle-Bisset 4. Cholecystokinin in intestinal and extraintestinal endocrine cellsMarta Santoz Hernandez, Frank Reimann, Fiona M. Gribble 5. Cholecystokinin in the central and peripheral nervous systemTomas Hökfelt, Swapnali Barde, Wen Zhong, Jufang He 6. Cholecystokinin 1 and cholecystokinin 2 receptorsLaurence J Miller 7. The relationship between cholecystokinin and gastrinJens F. Rehfeld Part III - Physiology of cholecystokinin8. Intestinal cholecystokinin secretionRashmi Chandra, Rodger A. Liddle 9. Cholecystokinin and the gut-brain axisKirsteen Browning, Amanda Page
- Cholecystokinin and the gallbladder
Adrian A. M. Masclee, Gwen M. C. Masclee 11. Cholecystokinin and the exocrine pancreasJohn A. Williams 12. Islet effects of cholecystokinin and exploitation in diabetesNeil Tanday, Nigel Irwin, Peter Flatt 13. Cholecystokinin and gastrointestinal motor functionJavad Anjom Shoae, Michael Horowitz, Christine Feinle-Bisset 14. Effect of cholecystokinin on food intake and appetiteFrank A. Duca 15. Cholecystokinin, nutrient preference and taste aversionJo E. Lewis, Fiona M. Gribble, Frank Reimann 16. Cholecystokinin in peripheral and central cardiovascular controlTony J. M. Verberne, Bashair M. Mussa 17. Cholecystokinin in cardiac myocytesJens P. Goetze, Jens F. Rehfeld Part IV - Methods used for cholecystokinin research18. Measurement of cholecystokinin in biological fluidsJens F. Rehfeld, Jens P. Goetze 19. Cholecystokinin knockout mice: peripheral and central phenotypesChunmin C. Lo, Dennis D. Black, Patrick Tso Part V - cholecystokinin in disease20. Cholecystokinin in obesity and other disorders of eatingKimberly R. Smith, Tim H. Moran 21. Cholecystokinin in tumorsJens F. Rehfeld 22. Cholecystokinin and panic disorderJacques Bradwejn, Diana Koszycki 23. Cholecystokinin and the immune systemJohn J. Worthington 24. Cholecystokinin in nociception and painNesia A. Zurek, Sascha R. A. Alles Part VI - cholecystokinin -based novel therapeutic approaches25. Potential therapeutics targeting cholecystokinin 1 receptorsLaurence J. Miller Part VII - Conclusion26. Reflections on cholecystokinin research: past, present and futureJens F. Rehfeld, Christine Feinle-Bisset
