Translational Gastroenterology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. Readers will learn important concepts, including case-control study, prospective cohort study, randomized trials, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in gastroenterology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation.The book provides valuable discussions of the critical appraisal of published studies in gastroenterology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or gastroenterologist who has ever had a good clinical idea but not the knowledge of how to test it.
- Provides a clear process for understanding, designing, executing, and analyzing translational and clinical research
- Presents practical and step-by-step guidance to help readers take ideas from the lab to the bedside
- Written by a team of experts who cover the breadth of translational research in Gastroenterology
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ISBN-13
978-0-12-821427-5 (9780128214275)
Schweitzer Klassifikation
PART I: CONCEPT1. Introduction to clinical research2. The question3. Study population4. Outcome measurementsPART II: STUDY TYPES5. Design principles6. Case series7. Case-control study8. Cohort study9. Cross-section study10. Clinical trials11. Meta-analysis12. Cost-effectiveness study13. Diagnostic test evaluation14. Reliability study15. Database studies16. Surveys and questionnaires17. Qualitative methods and mixed methods¿Definition of the study typePART III: CLINICAL TRIALS17. Randomized control18. Nonrandomized control19. Historical control20. Cross-over21. Withdrawal studies22. Factorial design23. Group allocation24. Hybrid design25. Large, pragmatic26. Equivalence and noninferiority27. Adaptive28. Randomization30. Multicenter considerations¿Study design and practical considerationsPART IV: PLANNING31. Optimizing the question32. Meaningful outcome measurements¿ 33. Sample size¿Power analysis34. Budgeting¿Funding, timeline, personnel, materials35. Ethics and review boards¿36. Regulatory considerations for new drugs and devices¿37. Funding approaches¿ 38. Research team¿39. Subject recruitment¿ 40. Data management¿ 41. Quality control¿ 42. Report forms43. Subject adherence¿ 44. Survival analysis¿ 45. Monitoring committee in clinical trialsPART V: STATISTICAL PRINCIPLES46. Presenting datä 47. Common issues in analysis¿ 48. Basic statistical principles¿ 49. Distributions¿Description, examples, implications in analysis. 50. Hypotheses and error types¿ 51. Power¿Detecting effects52. Regression¿Explanation53. t-test¿Explanation54. Chi-square¿Explanation55. Analysis of variance¿Explanation56. Correlation¿Explanation57. Biases¿
