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This book on the local and systemic manifestations and correlates of temporomandibular joint disorders (TMDs) encompasses the two intertwined facets of translational science - translational research and translational effectiveness - as they relate specifically to TMDs. The first part of the book, on recent translational research, focuses on topics such as the neuroanatomy and neurophysiology of the trigeminal nerve and trigeminal network system, the manifestations of neuroinflammation in TMDs, and the molecular mechanisms underlying TMDs. The second part discusses the clinical effectiveness of treatment approaches from the perspective of evidence-based dentistry, with careful attention to the critical relationships between dental malocclusions, the signs and symptoms of TMDs, and airway/breathing disorders. Interventions to correct for malocclusal conditions that lead to TMDs are examined, with explanation of the ways in which they can ameliorate a variety of local and systemic symptoms. This will be an excellent reference book for established practitioners, residents, interns, and students as well as a powerful cutting-edge document for researchers in the field.
"The book is a compelling plea for a better understanding of temporomandibular joint and airway disorders; it is a compelling guide for practitioners, residents, interns and students who want to deepen their knowledge in this area of dental practice." (Marian-Vladimir Constantinescu, Stomatology EDU Journal, Vol. 6 (4), 2019)
Andre Barkhordarian , M.S., Ph.D.; is a Project Scientist and a Lecturer in the Division of Oral Biology and Medicine at the UCLA School of Dentistry. He chairs an advanced course in Osteoimmunology and teaches courses in Immunology, Bone Biology, Biostatistics (research design, methodology, data analysis), Evidence Based Medicine and Dentistry. He is the faculty lecturer for the UCLA Pre-College Science Education Program, the STEM pipeline programs at UCLA School of Dentistry, and was the faculty consultant at the UCLA Graduate Division collaborating with internaland external stakeholders to increase fellowship resources. He has conducted translational research in the domain of Cell Biology, Osteoimmunology/Immunology for the pursuit of proteomic biomarkers of temporomandibular joint disorders (TMD), and related comorbid neurological pathologies. His research includes translational effectiveness, research synthesis methodology and data analysis (acceptable sampling analysis, meta-analysis, individual patient data analysis), and its implications and applications in Evidence-Based Medicine and Dentistry and its related areas of study. He is the Chief Executive Officer of the Evidence Based Decisions-Practice-Based Research Network and has published several articles and book chapters related to his research.
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