Drug-Drug Interactions

Introducing Pharmacokinetics and Pharmacodynamic Concepts. In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes. Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions. UDP-Glucuronosyltransferases. Drug-Drug Interactions Involving the Membrane Transport Process. In Vitro Models for Studying Induction of Cytochrome P450 Enzymes. In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450. The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development. Cytochrome P450 Protein Modeling and Ligand Docking. The Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions. Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations. Transporter-mediated Drug Interactions: Molecular Mechanisms and Clinical Implications. Metabolism & Transport Drug Interaction Database: a web-based research and analysis tool. In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans. Drug-Drug Interactions: Clinical Perspective. An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective. Drug-Drug Interactions: Toxicological Perspectives. Drug-Drug Interactions: Marketing Perspectives.