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Pharmaceutical biotechnology is a broad and growing field that can be defined as the science that covers all technologies required for the production, manufacturing, and registration of biological drugs. Most therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products and vaccines. Such bioformulations are developed through several stages that include understanding the principles underlying health and disease; the fundamental molecular mechanisms governing the function of related biomolecules; synthesis and purification of the molecules; determining the product shelf life, stability, toxicity and immunogenicity, drug delivery systems, patenting; and clinical trials. The future of pharmaceuticals belongs to protein-based therapeutics and soon to be mRNA vaccines. Designing stable and effective therapeutic proteins requires knowledge of protein structure and the interactions that stabilise the structure necessary for function.
The recent advancements in biotechnology, particularly in post-COVID era is accelerating the pace of research and development in all areas of biological sciences. Thus, the aim and scope of this book is to clearly illustrate ideas on diverse ongoing cutting-edge advancements in the field biotechnology and current scenario across a wide subject spectrum. The chapters are presented in a manner to update and provide comprehensive knowledge to the teachers, UG/PG students and research scholars and shall serve some interest for the public. This textbook is comprehensive in scope and concise in approach and ensures vital information pertaining to the advancements in biotechnology.
Ahmed Al-Harrasi is a professor of organic chemistry and the vice chancellor for graduate studies, research and external relations at the University of Nizwa. He obtained his BSc in Chemistry from SQU and his MSc and PhD in Organic Chemistry from Free University of Berlin as a DAAD-fellow. Then he received the Fulbright award in 2008 for postdoctoral research in Chemical Biology from Cornell University. He is a founder and chair of the Natural and Medical Sciences Research Center. He is a member of the Scientific Council of UNESCO. He was named on the list of top 2% Scientists for the last three years. He has authored over 800 scientific papers and more than 20 books and book chapters. He received the Order of Royal Commendation from His Majesty, The Sultan of Oman as an outstanding Omani individual for his remarkable contribution and active role in research.
Saurabh Bhatia is an Associate Professor within the Natural and Medical Sciences Research Centre at the University of Nizwa, Oman. He has published 79 referred journal articles and written 94 book chapters. Dr. Bhatia has also authored 10 books and is the Associate Editor on four international journals.
Saif Hameed is currently Associate Professor at Amity Institute of Biotechnology, Amity University Haryana (AUH). He has 70 peer-reviewed papers to his credit in international journals of repute, 26 book chapters and authored 9 books which include 4 from Springer-Nature and 1 from CRC Press, Taylor & Francis. He has supervised 6 Ph.D. students and guided 25 UG & PG level students for their research projects.
Zeeshan Fatima is currently Associate Professor at Amity Institute of Biotechnology, Amity University Haryana (AUH. She has 65 peer-reviewed papers to her credit in international journals of repute, 24 book chapters and authored 7 books including ones from Springer, Elsevier. She has supervised 5 Ph.D. students and guided 25 UG & PG level students for their research projects.
Preface
Acknowledgements
Editor Biographies
List of Contributors
1 History, scope and development of biotechnology
2 Modern DNA science and its applications
3 Introduction to genetic engineering
4 Applications of stem cells in disease and gene therapy
5 Transgenic animals in biotechnology
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