Strategies for Reducing Drug and Chemical Residues in Food Animals

Preface vii
Contributors ix
1 Importance of Veterinary Drug Residues 1
Ronald E. Baynes and Jim E. Riviere
2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination of Withdrawal Periods for Animal Drugs 9
Sanja Modric
3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals for Establishing Withdrawal Periods and Milk Discard Times 35
Dong Yan
4 Establishing Maximum Residue Limits in Europe 49
Kornelia Grein and Isaura Duarte
5 Methods to Derive Withdrawal Periods in the European Union 65
G. Johan Schefferlie and Stefan Scheid
6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81
Sharon E. Mason
7 Physiologically Based Pharmacokinetic Modeling 95
Jennifer Buur
8 Residue Avoidance in Beef Cattle Production Systems 115
Virginia Fajt and Dee Griffin
9 Residue Avoidance in Dairy Cattle Production Systems 137
Geof Smith
10 Residue Avoidance in Aquaculture Production Systems 161
Renate Reimschuessel
11 Residue Avoidance in Small Ruminant Production Systems 193
Kevin Anderson and Reha Azizoglu
12 Residue Avoidance in Swine Production Systems 221
Ronald E. Baynes and Glen Almond
13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities 233
Hui Li
14 The Food Animal Residue Avoidance Databank: An Example of Risk Management of Veterinary Drug Residues 289
Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere
15 Risk Management of Chemical Contaminants in Livestock 303
Ronald E. Baynes and Jim E. Riviere
Index 313