Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book.
The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists.
- Reviews all aspects of febrile seizures, including epidemiology, neurobiology and treatment
- Discusses novel and newly discovered information based on up-to the minute methods
- Provides an engaging style that is accessible to clinicians, researchers and educated parents
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-98418-8 (9780323984188)
Schweitzer Klassifikation
1. Incidence and prevalence of febrile seizures2. Who gets recurrent febrile seizures (also complex)3. Outcomes of febrile seizures: cognitive and epileptogenesis: B. Genetic and Acquired Syndromes Associated with Febrile Seizures4. The genetic landscape of febrile seizures and GEFS+5. SCN1A and Dravet syndrome6. Other channel syndromes7. FIRES and related syndromes C. Febrile Status Epilepticus8. Epidemiology of FSE9. Neuroimmune aspects of FSE10. FSE and TLE11. FSE and TLE- evolving therapeutic and surgical landscape12. Cognitive outcome of FSE D. The Neurobiology of FS and FSE: experimental approaches13. Why do febrile seizures involve the developing brain?14. Cytokines in FS rat models15. FS and FSE generation in rats and mice E. The Neurobiology of FSE-induced epilepsy and cognitive deficits: Experimental approaches16. The pathogenesis of FSE-induced epilepsy: Neuroinflammation and Epigenetics17. MicroRNAs and Epigenetic processes in FSE-provoked epilepsy18. HCN channels in human and rodent Epileptogenesis induced by FSE19. Cognitive problems following eFSE20. Predicting TLE-like epilepsy - the role of MRI: F. Clinical and Translational Implications of FSE21. MRI for assessing the impact of FSE and predicting outcomes22. EEG for assessing the impact of FSE and predicting outcome G. Management of febrile seizures and FSE- past, present and futures23. Evaluation and Practical Management approaches to simple and complex febrile seizures24. What do we tell parents of a child with simple or complex febrile seizures?25. The future of FS, FSE and their epileptogenic and cognitive outcomes
