Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.
This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs.
- Includes extensive classification of DMEs, their mechanism of action and computational analysis
- Covers the biotransformation of drug by DMEs and the possible impact of environmental contaminants
- Discusses the activity of DMEs in different clinical conditions such as cardiovascular disease, metabolic disorders, inflammation and neurotoxicity
- Includes modern and novel bioanalytical techniques to predict the effect of DMEs
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-95121-0 (9780323951210)
Schweitzer Klassifikation
1. Biochemical activation of drug metabolizing enzymes: From mechanism of action to functions2. Computational approaches and drug metabolizing enzymes: Concepts and challenges3. Biotransformation of drugs by drug metabolizing enzymes: Concepts and challenges4. Emerging environmental contaminants and drug metabolizing enzymes: Retrospective analysis and prospects5. Impact of prodrugs on drug metabolizing enzymes: From function to regulation6. Impact of hormones on drug metabolizing enzymes: From function to regulation7. Impact of receptors on drug metabolizing enzymes: From function to regulation8. Biochemistry of cathepsin enzymes and metabolic functions in lysosome9. Fate of drug metabolizing enzymes in metabolic diseases: Challenges and strategies10. Fate of drug metabolizing enzymes in cardiovascular diseases: Challenges and strategies11. Fate of drug metabolizing enzymes in neurological diseases: Challenges and strategies12. Impact of physiological factors on drug metabolizing enzymes: Challenges and strategies13. Xenobiotics and drug metabolizing enzymes: Challenges and strategies14. Drug metabolizing enzymes and inflammatory responses: Mechanism of induction and treatment strategies15. Polymorphism and drug metabolizing enzymes: Challenges and strategies16. Modulation of human microbiome and drug metabolism: Current trends and future prospects17. Bioanalytical techniques for prediction of metabolic activity of drug metabolizing enzymes: Challenges18. Role of pharmacogenomics for prediction of personalized medicines: Concepts and challenges19. Dietary sources of drug metabolizing enzymes: From production to regulation20. Vitamin deficiencies and drug metabolizing enzymes: Challenges and strategies21. Malnutrition and Drug metabolizing enzymes: Challenges and strategies22. Drug metabolizing enzymes and oxidative stress: Mechanism of induction and treatment strategies
