The examination of porphyrins and phthalocyanines and their metal complexes remains a pillar of the chemical sciences spanning fundamental chemistry and applications to biological chemistry and design of advanced materials. While the chemistry of the metalloporphyrins and metallophthalocyanines has been extensively explored, the metal chemistry of many of the analogs and isomers of the porphyrin macrocycle has only recently matured into a significant field. With recent significant advances in the organic chemistry of aromatic polypyrrolic macrocycles, leading to the easy availability of porphyrin analogs and isomers, research into the metal chemistry of these compounds is allowing a deeper understanding of their role in biochemistry and the development of new molecules with exciting applications in medicine, catalysis, materials science, and sensors. "Metal Chemistry of Porphyrinoids" summarizes these recent synthetic developments, particularly in respect of metallation strategies for freebase porphyrinoids, as well as progress towards applications in areas such as sensor and optical materials, catalysis and medicine.
This reference summarizes those developments as well as progress towards a variety of applications which mirror the many uses of normal porphyrins and phthalocyanines. Applications discussed include sensor and optical materials and medical applications, including radiopharmaceuticals and photodynamic therapy.
The examination of porphyrins and phthalocyanines and their metal complexes remains a pillar of the chemical sciences spanning fundamental chemistry and applications to biological chemistry and design of advanced materials. While the chemistry of the metalloporphyrins and metallophthalocyanines has been extensively explored, the metal chemistry of many of the analogs and isomers of the porphyrin macrocycle has only recently matured into a significant field. With recent significant advances in the organic chemistry of aromatic polypyrrolic macrocycles, leading to the easy availability of porphyrin analogs and isomers, research into the metal chemistry of these compounds is allowing a deeper understanding of their role in biochemistry and the development of new molecules with exciting applications in medicine, catalysis, materials science, and sensors. "Metal Chemistry of Porphyrinoids" summarizes these recent synthetic developments, particularly in respect of metallation strategies for freebase porphyrinoids, as well as progress towards applications in areas such as sensor and optical materials, catalysis and medicine.
This reference summarizes those developments as well as progress towards a variety of applications which mirror the many uses of normal porphyrins and phthalocyanines. Applications discussed include sensor and optical materials and medical applications, including radiopharmaceuticals and photodynamic therapy.
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978-0-8138-2212-9 (9780813822129)
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Christopher J. Ziegler is an assistant professor of chemistry at The University of Akron. He was a National Science Foundation Graduate Fellow at the University of Illinois at Urbana-Champaign, where he studied under Kenneth S. Suslick on synthetic porphyrin chemistry. He then moved to MIT, where he worked as a National Institutes of Health NRSA Fellow with Stephen J. Lippard researching the antitumor drug cisplatin. Prof. Ziegler has been at The University of Akron since 2000, and now works on the metal chemistry of porphyrin isomers, such as N-confused porphyrin, and analogs, such as corrole, porpholactone, and thiaporphyrins. G. Richard Geier III is an assistant professor of chemistry at Colgate University. He was a National Institutes of Health Graduate Training Fellow in Molecular Biotechnology at the University of Washington. His graduate studies under the direction of Tomikazu Sasaki entailed the preparation and study of a metalloporphyrin-peptide hybrid mimic of the cytochrome P450 family of enzymes. He then performed postdoctoral research with Jonathan S. Lindsey at North Carolina State University on the course of key reactions leading to meso-substituted porphyrins. The research provided insight into fundamental reactions while also affording practical observations such as the discovery of an efficient synthesis of N-confused porphyrin, and the identification of mild acid catalysts for condensations involving dipyrromethanecarbinol species. Prof. Geier has been at Colgate University since 2000, and now studies reactions leading to porphyrinoids with altered structures relative to porphyrin, such as corrole and [34]octaphyrin(1.1.1.0.1.1.1.0).
Christopher J. Ziegler is an assistant professor of chemistry at The University of Akron. He was a National Science Foundation Graduate Fellow at the University of Illinois at Urbana-Champaign, where he studied under Kenneth S. Suslick on synthetic porphyrin chemistry. He then moved to MIT, where he worked as a National Institutes of Health NRSA Fellow with Stephen J. Lippard researching the antitumor drug cisplatin. Prof. Ziegler has been at The University of Akron since 2000, and now works on the metal chemistry of porphyrin isomers, such as N-confused porphyrin, and analogs, such as corrole, porpholactone, and thiaporphyrins. G. Richard Geier III is an assistant professor of chemistry at Colgate University. He was a National Institutes of Health Graduate Training Fellow in Molecular Biotechnology at the University of Washington. His graduate studies under the direction of Tomikazu Sasaki entailed the preparation and study of a metalloporphyrin-peptide hybrid mimic of the cytochrome P450 family of enzymes. He then performed postdoctoral research with Jonathan S. Lindsey at North Carolina State University on the course of key reactions leading to meso-substituted porphyrins. The research provided insight into fundamental reactions while also affording practical observations such as the discovery of an efficient synthesis of N-confused porphyrin, and the identification of mild acid catalysts for condensations involving dipyrromethanecarbinol species. Prof. Geier has been at Colgate University since 2000, and now studies reactions leading to porphyrinoids with altered structures relative to porphyrin, such as corrole and [34]octaphyrin(1.1.1.0.1.1.1.0).
Chapter 1 Introduction.History and Scope.Investigating porphyrinoids using porphyrin as paradigm.Chapter 2 Metallation strategies for the porphryinoids.Challenges associated with these macrocycles.Traditional methods.New developments.Chapter 3 Isomeric porphyrins.Meso-carbon scrambled porphyrins.Confused and fused porphyrins.Chapter 4 Ring modified porphyrins.Core modified porphyrins (i.e. carbaporphyrin, thiaporphyrin).Reduced porphyrins (phlorins, chlorins).Oxidized porphyrins (porpholactone).Chapter 5 Contracted porphyrins.Subphthalocyanines.Corroles.Corrolozines.Chapter 6 Expanded porphyrins.Benziporphyrins.Sapphyrins.Octaphyrins.Chapter 7 Applications.Optical materials.Sensor materials.Catalysts.Medical applications (pholodynamic therapy, radiopharmaceuticals)
