Multiple Organ Failure.- From Celsus to Galen to Bone: The Illnesses, Syndromes, and Diseases of Acute Inflammation.- Towards Understanding Pathophysiology in Critical Care: the Human Body as a Complex System.- Pediatric Sepsis and Multiple Organ Failure at the Millenium: A US Perspective.- Ventilator-Associated Systemic Inflammation.- Affecting Clinical Outcomes in Acute Respiratory Distress Syndrome with Enteral Nutrition.- Reducing Surgical Mortality and Complications.- New Developments in Sepsis.- Toll-like Receptors: Imphcation in Human Disease.- Poly (ADP-ribose) synthetase as a Novel Therapeutic Target for Circulatory Shock.- Inhibition of p38 Mitogen Activated Protein Kinase: A Novel Strategy in Sepsis?.- Acute Adrenal Insufficiency in Critically Ill Patients: the Waterhouse-Friderichsen Syndrome Revisited.- Coagulation Abnormalities.- Natural Anticoagulants in Disseminated Intravascular Coagulation and Sepsis.- Changes of the Hemostatic Network in the Critically Ill.- Infectious Problems.- Education as a Primary Tool for Prevention of Catheter-related Infections.- Antibiotic Resistance in the Intensive Care Unit.- Fungal Infection in Critically Ill Patients.- The Heart.- The ?3-Adrenoceptor and its Regulation in Cardiac Tissue.- Quantifying Myocardial Ejection Asynchrony: Effective Stroke Volume Analysis.- Determination of Afterload: A Promising Challenge for Echocardiography?.- From the Heart to the Cell.- Regional Differences in Vascular Reactivity in Sepsis and Endotoxemia.- Initial Clinical Experience with OPS Imaging for Observation of the Human Microcirculation.- Usefulness of Gastric Tonometry in Critically Ill Patients.- Monitoring Tissue Gas Tensions in Critical Illness.- Cell Function.- Lactate, Lactate/Pyruvate Ratio, Low Tissue Perfusion andOutcome.- Mitochondrial Antioxidant Activity and Disease Processes.- Reactive Nitrogen and Oxygen Species: Role and Evidence of their Production in Humans.- A Possible Role for Iron Ions in Organ Injury.- Blood Transfusions.- Optimizing Red Blood Cell Transfusion Practice.- Augmented Acute Normovolemic Hemodilution.- Polytrauma.- Permissive Hypotension during Primary Resuscitation from Trauma and Shock.- Hypertonic Resuscitation for Traumatic Brain Injury?.- Neurologic Crisis.- Severe Head Injury in Patients with Multiple Trauma.- Humoral and Neurological Mechanisms of Organ System Dysfunction in Patients with Central Nervous System Disease.- Cerebral Function in Coma, Vegetative State, Minimally Conscious State, Locked-in Syndrome, and Brain Death.- Multimodality Evoked Potentials in the Confirmation of Brain Death.- Acute Respiratory Failure.- Measurement and Interpretation of Lung Mechanics in Patients with Acute Respiratory Failure.- Lung Recruitment and Stabilization in ARDS.- Proportional Pressure Support in Acute Lung Injury.- The Role of Helium in the Treatment of Acute Respiratory Failure.- Intra-tracheal Aerosol Delivery in Intubated Patients.- Airway Pressure Release Ventilation: Time to Change the Concept?.- Weaning from Mechanical Ventilation and Non-Invasive Ventilation.- Weaning from Mechanical Ventilation (Part 1): Evidence Supports the Use of Protocols.- Weaning from Mechanical Ventilation (Part 2): Strategies for Implementing Protocols.- Non-Invasive Ventilation and Weaning from Mechanical Ventilation.- Non-Invasive Ventilation in Acute Hypoxemic Respiratory Failure.- Non-Invasive Mechanical Ventilation in Chronic Obstructive Pulmonary Disease.- Intra-abdominal Pressure.- Intra-abdominal Pressure in the Intensive Care Unit: Clinical Tool or Toy?.- Measuring Intra-abdominal Pressure in Intensive Care Setting.- Liver, Pancreas and Kidney.- The Splanchnic Circulation in Cirrhosis and Portal Hypertension.- Indocyanine Green for the Assessment of Liver Function in Critically Ill Patients.- Liver Support Systems.- Pancreatic Dysfunction in Critical Illness.- Acute Dialysis Quality Initiative.- ICU Organization.- Optimal Interhospital Transport Systems for the Critically Ill.- Outreach: A Hospital-wide Approach to Critical Illness.- Randomized Clinical Trials in Pediatric Critical Care.- Clinical Information Systems in the ICU.- Creating and Maintaining Safe Systems of ICU Care.- Ethical Questions for the New Millennium.
