FK 506 and Organ Transplantation

This text examines FK 506, an immunosuppressant for recipients of solid organ transplants that can prevent allograft rejection. FK 506, like cyclosporine, inhibits calcium-dependent T-cell immune responses. FK 506 is the first drug that can substitute for cyclosporine as an immunosuppressant after organ transplantation. The work includes a comprehensive and critical review of the extensive clinical trials performed using this agent. It focuses on providing information necessary for transplant physicians and surgeons to decide how best to incorporate FK 506 into their immunosuppressive regimens.