I. Blood Safety Aspects.- Germs, Gels and Genomes. A Personal Recollection of 30 Years in Blood Safety Testing.- Quality Management for Blood Transfusion Services.- The Value of Donor Selection for Blood Safety.- Blood Donation; A Risk for Prenatal Developmental Toxicity?.- II. Transmissible Diseases.- Bacterial Contamination of Blood and Blood Products. An Underestimated Problem.- Parasites Transmitted by Blood Transfusion.- Prion Diseases and Blood Transfusion.- Tick-Borne Diseases: Recognized and Theoretical Risks Associated with Blood Transfusion.- Xeno-Transplantation and Xenozoonoses.- III. Transmissible Diseases.- NAT Update; Where Are We Today?.- Cost-Effectiveness of Alternatives to Allogeneic Blood Transfusion; Reviewing the Available Evidence.- Hereditary Metabolic Diseases and Stem Cell Transplantation.- Detection of Disease: Possibilities and Limitations.- IV. Preventative Aspects.- Quantitative Real-Time PCR for Detection of Parvovirus B19 DNA in Blood Plasma for Plasma Screening.- Advances in Bacterial Detection Technology.- Pathogen Inactivated Blood Components: Advancing from Theory to Practice.- GCBS, ICBS and Other Initiatives - The Pars Pro Toto Phenomenon; Will There Ever Be a Totum Pro Parte?.