Epidemiology.- The Importance of Acute Respiratory Failure in the ICU. The Epidemiology of Mechanical Ventilation. Long-term Outcomes of Mechanical Ventilation. Understanding and Changing the Practice of Mechanical Ventilation in the Community. Patient-ventilator Interactions, Weaning, and Monitoring.- Control of Breathing during Mechanical Ventilation. Patient-ventilator Interactions. Physiological Rationale for Ventilation of Patients with Obstructive Diseases. Role of the Clinician in adjusting Ventilator Parameters during Assisted Ventilation. Neurally-adjusted Ventilatory Assist. Liberating Patients from Mechanical Ventilation: What have we learned about Protocolizing Care?. Novel Approaches to Monitoring Mechanical Ventilatory Support.. Non-invasive Ventilation.- Indications for Non-invasive Ventilation. Non-invasive Ventilation: Causes of Success or Failure. Non-invasive Ventilation in Immunocompromised Patients. ARDS/VILI: Mechanisms,- Biophysical Factors leading to VILI. Vascular Contribution to VILI. VILI: Physiological Evidence. Systemic Effects of Mechanical Ventilation. ARDS/VILI: Assessment.- Chest Wall Mechanics in ARDS. Targets in Mechanical Ventilation for ARDS. How to Detect VILI at the Bedside?. Lung Morphology in ARDS: How it impacts Therapy. ARDS/VILI: Therapy.- Recruitment Maneuvers in ARDS. Spontaneous Breathing during Ventilatory Support in Patients with ARDS. Pressure-support Ventilation in Patients with ALI/ARDS. Prone Ventilation. Adjuncts to Mechanical Ventilation for ARDS including Biological Variability. Summary of Clinical Trials of Mechanical Ventilation in ARDS. Subject Index