Part 1 Initial stages: handling the original idea, J.S.Calnan; the choice of an experimental model, K.C.Calman; applying for a research grant, J.S.Calnan. Part 2 Clinical research: the controlled clinical research, I.S.Benjamin and S.Boesby; controlling variables - anaesthesia, G.M.Hall; - metabolism, J.A.R.Smith; research in a district general hospital, M.W.L.Gear. Part 3 Computers: overview of computers, S.Lewis; application of computers, A.W.Murray and G.N.E.Kenny; database management systems, J.B.Roussak. Part 4 Statistics: introduction to statistics, H.A.F.Dudley; descriptive statistics, M.Aldridge; statistical tests, H.A.F.Dudley; life tables, R.K.S.Phillips. Part 5 How to do it: how to use a library, L.A.Curtis; how to write a paper for publication, W.Fitch; how to present a paper at a scientific meeting, J.H.Baron; how to write and submit a thesis, M.J.Kelly; how to illustrate publications and presentations, D.Simmonds.